Marchf1 membrane associated ring-CH-type finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Marchf1provided by RGD
Full Name: membrane associated ring-CH-type finger 1provided by RGD
Primary source: RGD:1305148
See related: EnsemblRapid:ENSRNOG00000026310 AllianceGenome:RGD:1305148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: March1; RGD1305148
Summary: Predicted to enable MHC protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; lysosomal membrane; and trans-Golgi network membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 150.6), Thymus (RPKM 36.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14-p13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (28022159..28880872, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (23255551..24114290, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (24998709..25856327, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BI301985 (e-PCR)
- UniSTS:247073

RH138482 (e-PCR)
- UniSTS:220569

D16Got26 (e-PCR)
- UniSTS:113891

RH144480 (e-PCR)
- UniSTS:233725

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF1

Names: E3 ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein ligase MARCH1-like; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

NP_001129310.1

EC 2.3.2.27

NP_001388434.1

EC 2.3.2.27

XP_008769356.3

EC 2.3.2.27

XP_017455664.2

EC 2.3.2.27

XP_017455665.2

EC 2.3.2.27

XP_038950560.1

EC 2.3.2.27

XP_038950561.1

EC 2.3.2.27

XP_038950562.1

EC 2.3.2.27

XP_038950563.1

EC 2.3.2.27

XP_063131582.1

EC 2.3.2.27

XP_063131583.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135838.2 → NP_001129310.1 E3 ubiquitin-protein ligase MARCHF1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D4A6K8

Related

ENSRNOP00000102883.1, ENSRNOT00000148808.1

Conserved Domains (1) summary

cd16698
Location:75 → 126

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
NM_001401505.1 → NP_001388434.1 E3 ubiquitin-protein ligase MARCHF1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

Related

ENSRNOP00000092175.2, ENSRNOT00000110592.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

28022159..28880872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600176.3 → XP_017455665.2 E3 ubiquitin-protein ligase MARCHF1 isoform X2

Conserved Domains (1) summary

cd16698
Location:332 → 383

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_039094632.2 → XP_038950560.1 E3 ubiquitin-protein ligase MARCHF1 isoform X1

UniProtKB/TrEMBL

A0A8I6AH31

Conserved Domains (1) summary

cd16698
Location:332 → 383

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_039094634.2 → XP_038950562.1 E3 ubiquitin-protein ligase MARCHF1 isoform X3

Conserved Domains (1) summary

cd16698
Location:328 → 379

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_008771134.4 → XP_008769356.3 E3 ubiquitin-protein ligase MARCHF1 isoform X5

Conserved Domains (1) summary

cd16698
Location:79 → 130

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_039094635.2 → XP_038950563.1 E3 ubiquitin-protein ligase MARCHF1 isoform X4

UniProtKB/TrEMBL

A0A8I6AQF1

Related

ENSRNOP00000101945.1, ENSRNOT00000157784.1

Conserved Domains (1) summary

cd16698
Location:79 → 130

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_063275512.1 → XP_063131582.1 E3 ubiquitin-protein ligase MARCHF1 isoform X3
XM_039094633.2 → XP_038950561.1 E3 ubiquitin-protein ligase MARCHF1 isoform X3

Conserved Domains (1) summary

cd16698
Location:328 → 379

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_017600175.3 → XP_017455664.2 E3 ubiquitin-protein ligase MARCHF1 isoform X1

UniProtKB/TrEMBL

A0A8I6AH31

Related

ENSRNOP00000100848.1, ENSRNOT00000160934.1

Conserved Domains (1) summary

cd16698
Location:332 → 383

RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins
XM_063275513.1 → XP_063131583.1 E3 ubiquitin-protein ligase MARCHF1 isoform X6

UniProtKB/TrEMBL

A6KFM4