Galr1 galanin receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Galr1provided by RGD
Official Full Name: galanin receptor 1provided by RGD
Primary source: RGD:2656
See related: EnsemblRapid:ENSRNOG00000016654 AllianceGenome:RGD:2656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Galnr1
Summary: Enables galanin receptor activity and neuropeptide binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in nicotine dependence and opiate dependence. Orthologous to human GALR1 (galanin receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 8.2) and Thymus (RPKM 1.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (78046803..78062359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (75772021..75787577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (79243009..79258570, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3beta/TIP60 Pathway After Subarachnoid Hemorrhage in Rats.
Title: Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis via ERK/GSK-3β/TIP60 Pathway After Subarachnoid Hemorrhage in Rats.
Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray.
Title: Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray.
These results illustrated that galanin induced antinociception in CeA in normal rats and rats with neuropathy, and there is an up-regulation of GalR1 expression in rats with neuropathy.
Title: Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
The inhibitory effect of galanin on locus coeruleus neurons is mediated by GALR1 via Gi/o proteins, which activate GIRK channels.
Title: Activation of galanin receptor 1 inhibits locus coeruleus neurons via GIRK channels.
the depression-like behavior in rats exposed to chronic mild stress is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.
Title: Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.
PG early treatment prevented Y1R upregulation and resulted in lower NPY, Y2R and GalR1 mRNA levels. In the chronic phase, injured rats showed well-established mechanical and cold allodynia and significant increases in galanin, NPY, GalR1 and Y1R mRNAs, while maintaining reduced GalR2 expression. Animals receiving PG treatment showed basal expression levels of galanin, NPY, GalR1 and Y1R, and reduced Y2R mRNA levels
Title: Spinal neuropeptide expression and neuropathic behavior in the acute and chronic phases after spinal cord injury: Effects of progesterone administration.
the central effect of GALR1 agonist M617 on insulin resistance in skeletal muscle and its underlying mechanisms.
Title: Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway.
Suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats.
Title: Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.
The sensitivity of GluA4 AMPA receptors to human galectin-1 could be enhanced by supplementation of culture media with uridine and N-acetylglucosamine (GlcNAc), precursors for hexosamine pathway that supplies UDP-GlcNAc for synthesis of oligosaccharides.
Title: Modulation of ionotropic glutamate receptor function by vertebrate galectins.
Transient occlusion of the middle cerebral artery altered GalR1 gene expression in rat brain supportting the notion that GalR1 may play a role in the response of the central nervous system to injury.
Title: Changes in galanin and GalR1 gene expression in discrete brain regions after transient occlusion of the middle cerebral artery in female rats.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Markers

D18Chm74 (e-PCR)
- UniSTS:518237

D18Chm73 (e-PCR)
- UniSTS:518280

RH94734 (e-PCR)
- UniSTS:119981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables galanin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables galanin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables galanin receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cortisol secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: galanin receptor type 1

Names: GAL1-R; GALR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012958.3 → NP_037090.2 galanin receptor type 1

See identical proteins and their annotated locations for NP_037090.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018, U30290

UniProtKB/Swiss-Prot

Q62805

UniProtKB/TrEMBL

A6K5J0

Related

ENSRNOP00000022400.1, ENSRNOT00000022401.4

Conserved Domains (1) summary

cd15098
Location:33 → 312

7tmA_Gal1_R; galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors