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    Slc12a3 solute carrier family 12 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54300, updated on 27-Nov-2024

    Summary

    Symbol
    Slc12a3provided by RGD
    Full Name
    solute carrier family 12 member 3provided by RGD
    Primary source
    RGD:3686
    See related
    EnsemblRapid:ENSRNOG00000057072 AllianceGenome:RGD:3686
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NCC; TSC
    Summary
    Enables enzyme binding activity and sodium:chloride symporter activity. Involved in chloride transport and sodium ion transmembrane transport. Located in apical plasma membrane and vesicle. Is active in plasma membrane. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 821.7) See more
    Orthologs
    NEW
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    Genomic context

    See Slc12a3 in Genome Data Viewer
    Location:
    19p13-p12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10636594..10690008, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10630651..10679250, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (11106033..11144674, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene NLR family, CARD domain containing 5 Neighboring gene uncharacterized LOC134483688 Neighboring gene uncharacterized LOC102553339 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1 Neighboring gene uncharacterized LOC120098571 Neighboring gene microRNA 138-2 Neighboring gene nucleoporin 93 Neighboring gene metallothionein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:chloride symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:chloride symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal sodium ion absorption IC
    Inferred by Curator
    more info
    PubMed 
    involved_in renal sodium ion absorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in renal sodium ion absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to aldosterone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier family 12 member 3
    Names
    Na-Cl symporter
    solute carrier family 12 (sodium/chloride transporter), member 3
    solute carrier family 12 (sodium/chloride transporters), member 3
    thiazide-sensitive Na-Cl cotransporter
    thiazide-sensitive sodium-chloride cotransporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019345.4NP_062218.3  solute carrier family 12 member 3

      See identical proteins and their annotated locations for NP_062218.3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P55018
      UniProtKB/TrEMBL
      A6JY68, G3V8G0
      Related
      ENSRNOP00000070064.1, ENSRNOT00000081246.3
      Conserved Domains (1) summary
      TIGR00930
      Location:571001
      2a30; K-Cl cotransporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10636594..10690008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278264.1XP_063134334.1  solute carrier family 12 member 3 isoform X1

    2. XM_063278266.1XP_063134336.1  solute carrier family 12 member 3 isoform X3

    3. XM_063278265.1XP_063134335.1  solute carrier family 12 member 3 isoform X2