Cck cholecystokinin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cckprovided by RGD
Official Full Name: cholecystokininprovided by RGD
Primary source: RGD:2288
See related: AllianceGenome:RGD:2288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables neuropeptide hormone activity. Involved in several processes, including learning or memory; positive regulation of protein metabolic process; and regulation of behavioral fear response. Located in several cellular components, including axon; dendrite; and perikaryon. Is active in GABA-ergic synapse and neuronal dense core vesicle lumen. Used to study cataract. Human ortholog(s) of this gene implicated in alcohol dependence and nicotine dependence. Orthologous to human CCK (cholecystokinin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 513.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130031012..130037702, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121153499..121160194, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130120525..130127515, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The critical role of CCK in the regulation of food intake and diet-induced obesity.
Title: The critical role of CCK in the regulation of food intake and diet-induced obesity.
The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.
Title: The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue.
results show that cholecystokinin promotes lipid storage in white adipose tissue by acting on adipocyte cholecystokinin-2 receptor
Title: Cholecystokinin is involved in triglyceride fatty acid uptake by rat adipose tissue.
Study provides the first direct comparative and quantitative data showing that presynaptic GABAB receptors exert differential inhibition at cholecystokinin (CCK) and parvalbumin (PV) basket cell (BC) synapses, resulting from a higher surface expression of the receptor at all CCK BC terminals and a lower protein density present in a subpopulation of boutons of PV BCs.
Title: Differential surface density and modulatory effects of presynaptic GABA(B) receptors in hippocampal cholecystokinin and parvalbumin basket cells.
The two projections from CCK(NTS) neurons reduce food intake through opposite motivational states; one pathway signals positive valence (CCK(NTS)-->paraventricular nucleus of the hypothalamus ) and the other signals negative valence (CCK(NTS)-->parabrachial nucleus).
Title: A tale of two circuits: CCK(NTS) neuron stimulation controls appetite and induces opposing motivational states by projections to distinct brain regions.
Taken together, these results demonstrate that DMH NPY descending signals affect CCK-induced satiety, at least in part, via modulation of NTS catecholaminergic neuronal signaling.
Title: Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brain stem catecholamine neuronal signaling.
We conclude that only a small fraction of neuronal CCK is nonsulfated. The intracellular distribution of nonsulfated CCK in neurons suggests that they contribute only modestly to the CCK transmitter activity.
Title: Nonsulfated cholecystokinins in cerebral neurons.
The favorable treatment strategy for acute pancreatitis is to keep the pancreas at rest during an early stage followed by pancreatic stimulation by promoting endogenous CCK release.
Title: Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
Cardiac expression of pro-cholecystokinin is cell-specific, which differentiates the expression from that of intestinal endocrine cells and cerebral neurons.
Title: Cardiomyocyte expression and cell-specific processing of procholecystokinin.
Estrogen-induced anxiolytic effects were associated with changes of the cholecystokinin system in brain regions controlling anxiety-like behavior.
Title: Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol.

Submit: New GeneRIF Correction See all GeneRIFs (53)

General gene information

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Markers

Cck (e-PCR), detects polymorphism
- UniSTS:495981

RH94468 (e-PCR)
- UniSTS:119716

RH94772 (e-PCR)
- UniSTS:120019

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cholecystokinin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in digestion	IBA Inferred from Biological aspect of Ancestor more info
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eating behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of behavioral fear response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in axon hillock	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cholecystokinin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012829.2 → NP_036961.1 cholecystokinin preproprotein

See identical proteins and their annotated locations for NP_036961.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P01355

UniProtKB/TrEMBL

A6I437

Conserved Domains (1) summary

pfam00918
Location:4 → 115

Gastrin; Gastrin/cholecystokinin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

130031012..130037702 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080873.2 → XP_038936801.1 cholecystokinin isoform X1

Conserved Domains (1) summary

pfam00918
Location:4 → 141

Gastrin; Gastrin/cholecystokinin family