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    Lhfpl2 LHFPL tetraspan subfamily member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294643, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lhfpl2provided by RGD
    Official Full Name
    LHFPL tetraspan subfamily member 2provided by RGD
    Primary source
    RGD:1309869
    See related
    EnsemblRapid:ENSRNOG00000011032 AllianceGenome:RGD:1309869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in development of primary female sexual characteristics; development of primary male sexual characteristics; and positive regulation of fertilization. Predicted to be active in membrane. Orthologous to human LHFPL2 (LHFPL tetraspan subfamily member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 109.5), Heart (RPKM 64.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lhfpl2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27016404..27169830)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (25281771..25428128)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (23705491..23852021)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA24 Neighboring gene arylsulfatase B Neighboring gene uncharacterized LOC120100667 Neighboring gene SNRPN upstream open reading frame, pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 5 Neighboring gene secretory carrier membrane protein 1 Neighboring gene adaptor related protein complex 3 subunit beta 1 Neighboring gene uncharacterized LOC108349922

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel function of LHFPL2 in female and male distal reproductive tract development. Zhao F, et al. Sci Rep, 2016 Mar 11. PMID 26964900, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in development of primary female sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in development of primary male sexual characteristics ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LHFPL tetraspan subfamily member 2 protein
    Names
    lipoma HMGIC fusion partner-like 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106402.2 → NP_001099872.1  LHFPL tetraspan subfamily member 2 protein

      See identical proteins and their annotated locations for NP_001099872.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4W3, D4A0X7
      Conserved Domains (1) summary
      pfam10242
      Location:9 → 196
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    2. NM_001429144.1 → NP_001416073.1  LHFPL tetraspan subfamily member 2 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I4W3, D4A0X7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      27016404..27169830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281486.1 → XP_063137556.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    2. XM_017590688.3 → XP_017446177.1  LHFPL tetraspan subfamily member 2 protein isoform X3

      Related
      ENSRNOP00000014795.5, ENSRNOT00000014795.9
      Conserved Domains (1) summary
      pfam10242
      Location:9 → 196
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    3. XM_039101911.2 → XP_038957839.1  LHFPL tetraspan subfamily member 2 protein isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:9 → 200
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    4. XM_063281488.1 → XP_063137558.1  LHFPL tetraspan subfamily member 2 protein isoform X3

    5. XM_063281487.1 → XP_063137557.1  LHFPL tetraspan subfamily member 2 protein isoform X1

    6. XM_039101908.2 → XP_038957836.1  LHFPL tetraspan subfamily member 2 protein isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:9 → 200
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    7. XM_017590692.3 → XP_017446181.1  LHFPL tetraspan subfamily member 2 protein isoform X3

      UniProtKB/TrEMBL
      A6I4W3, D4A0X7
      Conserved Domains (1) summary
      pfam10242
      Location:9 → 196
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    8. XM_039101909.2 → XP_038957837.1  LHFPL tetraspan subfamily member 2 protein isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:9 → 200
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    9. XM_039101912.2 → XP_038957840.1  LHFPL tetraspan subfamily member 2 protein isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:9 → 200
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    10. XM_063281489.1 → XP_063137559.1  LHFPL tetraspan subfamily member 2 protein isoform X3

      UniProtKB/TrEMBL
      A6I4W3, D4A0X7
    Nucleotide Protein Strain
    Heading Accession and Version

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