Slc35a1 solute carrier family 35 member A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc35a1provided by RGD
Official Full Name: solute carrier family 35 member A1provided by RGD
Primary source: RGD:1311359
See related: EnsemblRapid:ENSRNOG00000008908 AllianceGenome:RGD:1311359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CMP-N-acetylneuraminate transmembrane transporter activity and antiporter activity. Predicted to be involved in CMP-N-acetylneuraminate transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIf. Orthologous to human SLC35A1 (solute carrier family 35 member A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 153.0), Adrenal (RPKM 88.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (54021896..54044677, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (49225599..49248382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (50119880..50142689, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143460 (e-PCR)
- UniSTS:232707

Slc35a1 (e-PCR), detects polymorphism
- UniSTS:547083

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CMP-N-acetylneuraminate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables CMP-N-acetylneuraminate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CMP-N-acetylneuraminate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in CMP-N-acetylneuraminate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in CMP-N-acetylneuraminate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CMP-sialic acid transporter

Names: solute carrier family 35 (CMP-sialic acid transporter), member 1; solute carrier family 35 (CMP-sialic acid transporter), member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107924.2 → NP_001101394.2 CMP-sialic acid transporter

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2JZH4, D3ZZ48

Related

ENSRNOP00000071048.1, ENSRNOT00000081150.3

Conserved Domains (1) summary

pfam04142
Location:8 → 314

Nuc_sug_transp; Nucleotide-sugar transporter