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    Meis1 Meis homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686117, updated on 27-Dec-2024

    Summary

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    Symbol
    Meis1provided by RGD
    Full Name
    Meis homeobox 1provided by RGD
    Primary source
    RGD:1585482
    See related
    EnsemblRapid:ENSRNOG00000004606 AllianceGenome:RGD:1585482
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in cell growth involved in cardiac muscle cell development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 362.7), Lung (RPKM 186.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Meis1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (97356949..97499646, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (93155426..93294373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (103182178..103321809, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096677 Neighboring gene uncharacterized LOC120096678 Neighboring gene uncharacterized LOC134481793 Neighboring gene uncharacterized LOC103693204 Neighboring gene uncharacterized LOC108352806

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension. Yao MZ, et al. Life Sci, 2020 Aug 15. PMID 32450174
    2. Effect of changes in food consistency on NADH-ubiquinone oxidoreductase activity and levels of mRNA for ND1, 51kDa, 75kDa and myosin heavy chain isoforms in two different portions of rat masseter muscle. Ide Y, et al. Okajimas Folia Anat Jpn, 2006 Aug. PMID 16944839
    3. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins. Chang CP, et al. Mol Cell Biol, 1997 Oct. PMID 9315626, Free PMC Article
    4. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. Hisa T, et al. EMBO J, 2004 Jan 28. PMID 14713950, Free PMC Article
    5. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Liu J, et al. Proc Natl Acad Sci U S A, 2010 Nov 23. PMID 21059917, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEIS1 regulated the proliferation and migration of pulmonary artery smooth muscle cells during hypoxia-induced pulmonary hypertension
      Title: MEIS1 regulated proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lens morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis1
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134702.1 → NP_001128174.1  homeobox protein Meis1

      See identical proteins and their annotated locations for NP_001128174.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161984
      UniProtKB/TrEMBL
      B1WC31, F7EL40
      Related
      ENSRNOP00000006157.6, ENSRNOT00000006157.7
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      97356949..97499646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273629.1 → XP_063129699.1  homeobox protein Meis1 isoform X3

      UniProtKB/TrEMBL
      A6JQ06
      Related
      ENSRNOP00000089570.2, ENSRNOT00000104415.2

    2. XM_006251529.5 → XP_006251591.1  homeobox protein Meis1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMM6, A6JQ06
      Conserved Domains (3) summary
      TIGR01628
      Location:326 → 449
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. XM_063273628.1 → XP_063129698.1  homeobox protein Meis1 isoform X2

      UniProtKB/TrEMBL
      A6JQ06

    4. XM_039092455.2 → XP_038948383.1  homeobox protein Meis1 isoform X6

      Conserved Domains (2) summary
      TIGR01628
      Location:163 → 286
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05920
      Location:127 → 166
      Homeobox_KN; Homeobox KN domain

    5. XM_039092454.2 → XP_038948382.1  homeobox protein Meis1 isoform X4

      UniProtKB/TrEMBL
      B1WC31, F7EL40
      Conserved Domains (2) summary
      pfam05920
      Location:290 → 329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108 → 192
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_063273630.1 → XP_063129700.1  homeobox protein Meis1 isoform X5

      UniProtKB/TrEMBL
      F7EL40

    RNA

    1. XR_005493013.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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