Bbc3 Bcl-2 binding component 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bbc3provided by RGD
Official Full Name: Bcl-2 binding component 3provided by RGD
Primary source: RGD:631434
See related: EnsemblRapid:ENSRNOG00000062473 AllianceGenome:RGD:631434
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Puma
Summary: Predicted to enable ATPase binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in lysosome. Predicted to be active in mitochondrion. Biomarker of intermittent claudication and transient cerebral ischemia. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 26.3), Liver (RPKM 22.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86141450..86150666)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77013281..77022509)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78261491..78267802)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease.
Title: Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease.
[Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes induced by high glucose].
Title: [Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes induced by high glucose].
LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by up-regulated PUMA under hypoxia condition.
Title: LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by up-regulated PUMA under hypoxia condition.
These results demonstrated the involvement of BBC3/Bbc3 in cold preservation/rewarming-mediated islet injury, possibly through modulating HMGB1- and oxidative stress-mediated injury to islets.
Title: Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming.
Reduction of p53 upregulated modulator of apoptosis (PUMA) expression mediates the endogenous cardioprotective mechanisms of postconditioning by disrupting mitochondrial apoptotic pathway.
Title: PUMA-mediated mitochondrial apoptotic disruption by hypoxic postconditioning.
we identified a novel AP1-binding site on rat puma gene which is necessary for direct binding of c-Jun with Puma promoter
Title: The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death.
Puma is activated by both p53 and PI3K/Akt/FoxO3a pathways and cooperates with Bim to induce neuron death in response to Abeta(1-42)
Title: The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.
over-expression of PUMA correlates with cauda equina compression caused apoptosis of spinal cord cells
Title: Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model.
An in vivo model of aorta-caval shunt and aortic banding showed increased PUMA protein expression in the aorta.
Title: Mechanical stretch induces the apoptosis regulator PUMA in vascular smooth muscle cells.
After the administration of paraquat, the levels of PUMA, cleaved caspase-3, and APE increased in a time-dependent manner, indicating that PQ-induced nephrotoxicity was caused by activation of the apoptotic pathway.
Title: Protective effects of chitosan oligosaccharide on paraquat-induced nephrotoxicity in rats.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH70710 (e-PCR)
- UniSTS:9537

BBC3_3813 (e-PCR)
- UniSTS:463239

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in T cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of establishment of protein localization to mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of thymocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2-binding component 3

Names: p53 up-regulated modulator of apoptosis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173837.2 → NP_776209.1 bcl-2-binding component 3

See identical proteins and their annotated locations for NP_776209.1

Status: PROVISIONAL

Source sequence(s)

AY157758

UniProtKB/Swiss-Prot

Q80ZG6

UniProtKB/TrEMBL

A6J8A5

Conserved Domains (1) summary

pfam15826
Location:2 → 193

PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86141450..86150666

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080914.2 → XP_038936842.1 bcl-2-binding component 3 isoform X1
XM_039080925.2 → XP_038936853.1 bcl-2-binding component 3 isoform X3

UniProtKB/Swiss-Prot

Q80ZG6

UniProtKB/TrEMBL

A6J8A5

Conserved Domains (1) summary

pfam15826
Location:2 → 193

PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
XM_039080919.2 → XP_038936847.1 bcl-2-binding component 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AHA0

Related

ENSRNOP00000092134.1, ENSRNOT00000096062.2

Conserved Domains (1) summary

pfam15826
Location:18 → 209

PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis