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    Tex14 testis expressed 14, intercellular bridge forming factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287603, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tex14provided by RGD
    Official Full Name
    testis expressed 14, intercellular bridge forming factorprovided by RGD
    Primary source
    RGD:1305437
    See related
    EnsemblRapid:ENSRNOG00000023698 AllianceGenome:RGD:1305437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear chromosome segregation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor and negative regulation of cytokinesis. Predicted to be located in cytoplasm. Predicted to be active in intercellular bridge; kinetochore; and midbody. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 114.1) and Kidney (RPKM 13.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tex14 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72729017..72859697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72231766..72356938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74724070..74849172)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480845 Neighboring gene RAD51 paralog C Neighboring gene uncharacterized LOC134480851 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480849 Neighboring gene transfer RNA asparagine (anticodon GUU) 9 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134480850 Neighboring gene small nucleolar RNA U3 Neighboring gene U4 spliceosomal RNA Neighboring gene small nucleolar RNA U3 Neighboring gene zinc finger protein OZF-like Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC134480848 Neighboring gene septin 4 Neighboring gene myotubularin related protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Conversion of midbodies into germ cell intercellular bridges. Greenbaum MP, et al. Dev Biol, 2007 May 15. PMID 17383626, Free PMC Article
    2. TEX14 is essential for intercellular bridges and fertility in male mice. Greenbaum MP, et al. Proc Natl Acad Sci U S A, 2006 Mar 28. PMID 16549803, Free PMC Article
    3. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. Mondal G, et al. Mol Cell, 2012 Mar 9. PMID 22405274, Free PMC Article
    4. TEX14 interacts with CEP55 to block cell abscission. Iwamori T, et al. Mol Cell Biol, 2010 May. PMID 20176808, Free PMC Article
    5. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intercellular bridge organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intercellular bridge organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intercellular bridge organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intercellular bridge organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid separation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intercellular bridge IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine/threonine-protein kinase TEX14
    Names
    testis expressed gene 14
    testis-expressed protein 14
    testis-expressed sequence 14 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419556.1 → NP_001406485.1  inactive serine/threonine-protein kinase TEX14

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOP00000009077.8, ENSRNOT00000009077.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72729017..72859697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087362.2 → XP_038943290.1  inactive serine/threonine-protein kinase TEX14 isoform X1

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039087366.2 → XP_038943294.1  inactive serine/threonine-protein kinase TEX14 isoform X5

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039087365.2 → XP_038943293.1  inactive serine/threonine-protein kinase TEX14 isoform X3

      UniProtKB/Swiss-Prot
      F1M5M3
      Related
      ENSRNOP00000090596.2, ENSRNOT00000116997.2
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039087369.2 → XP_038943297.1  inactive serine/threonine-protein kinase TEX14 isoform X8

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039087364.2 → XP_038943292.1  inactive serine/threonine-protein kinase TEX14 isoform X2

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    6. XM_063268693.1 → XP_063124763.1  inactive serine/threonine-protein kinase TEX14 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANJ7

    7. XM_039087370.2 → XP_038943298.1  inactive serine/threonine-protein kinase TEX14 isoform X9

      UniProtKB/TrEMBL
      J3KTR9
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    8. XM_039087371.2 → XP_038943299.1  inactive serine/threonine-protein kinase TEX14 isoform X10

      UniProtKB/TrEMBL
      J3KTR9
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    9. XM_063268694.1 → XP_063124764.1  inactive serine/threonine-protein kinase TEX14 isoform X11

    10. XM_039087373.2 → XP_038943301.1  inactive serine/threonine-protein kinase TEX14 isoform X12

      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    11. XM_039087363.2 → XP_038943291.1  inactive serine/threonine-protein kinase TEX14 isoform X1

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:72 → 220
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:27 → 53
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:27 → 119
      Ank_2; Ankyrin repeats (3 copies)
      cl21453
      Location:270 → 507
      PKc_like; Protein Kinases, catalytic domain

    12. XM_039087368.2 → XP_038943296.1  inactive serine/threonine-protein kinase TEX14 isoform X7

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:32 → 180
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:15 → 46
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:18 → 61
      Ank_4; Ankyrin repeats (many copies)
      cl21453
      Location:230 → 467
      PKc_like; Protein Kinases, catalytic domain

    13. XM_039087367.2 → XP_038943295.1  inactive serine/threonine-protein kinase TEX14 isoform X6

      UniProtKB/Swiss-Prot
      F1M5M3
      Conserved Domains (4) summary
      PTZ00322
      Location:34 → 182
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      sd00045
      Location:17 → 48
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:20 → 63
      Ank_4; Ankyrin repeats (many copies)
      cl21453
      Location:232 → 469
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1M5M3.2 GenPept UniProtKB/Swiss-Prot:F1M5M3

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