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    Megf11 multiple EGF-like-domains 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691517, updated on 27-Nov-2024

    Summary

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    Symbol
    Megf11provided by RGD
    Full Name
    multiple EGF-like-domains 11provided by RGD
    Primary source
    RGD:1582797
    See related
    EnsemblRapid:ENSRNOG00000010634 AllianceGenome:RGD:1582797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable scavenger receptor activity. Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in membrane. Orthologous to human MEGF11 (multiple EGF like domains 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 75.5), Brain (RPKM 70.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Megf11 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73787568..74113228)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64892312..65218984)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69859256..70191070)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 14 Neighboring gene timeless interacting protein Neighboring gene DIS3-like exosome 3'-5' exoribonuclease Neighboring gene uncharacterized LOC134480194 Neighboring gene transfer RNA glutamine (anticodon CUG) 5 Neighboring gene RAB11a, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Kay JN, et al. Nature, 2012 Mar 11. PMID 22407321, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiple EGF-like-domains 11; multiple epidermal growth factor-like domains protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430417.1 → NP_001417346.1  multiple EGF-like-domains 11 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GF09

    2. NM_001430418.1 → NP_001417347.1  multiple EGF-like-domains 11 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_001430419.1 → NP_001417348.1  multiple EGF-like-domains 11 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_001430420.1 → NP_001417349.1  multiple EGF-like-domains 11 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    5. NM_001430421.1 → NP_001417350.1  multiple EGF-like-domains 11 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    6. NM_001430422.1 → NP_001417351.1  multiple EGF-like-domains 11 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    7. NM_001430423.1 → NP_001417352.1  multiple EGF-like-domains 11 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    8. NM_001430424.1 → NP_001417353.1  multiple EGF-like-domains 11 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      73787568..74113228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082458.2 → XP_038938386.1  multiple epidermal growth factor-like domains protein 11 isoform X11

      UniProtKB/TrEMBL
      F1M1F5
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    2. XM_039082447.2 → XP_038938375.1  multiple epidermal growth factor-like domains protein 11 isoform X1

      UniProtKB/TrEMBL
      F1LVJ8
      Conserved Domains (3) summary
      pfam00053
      Location:275 → 320
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:189 → 234
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    3. XM_063266407.1 → XP_063122477.1  multiple epidermal growth factor-like domains protein 11 isoform X2

    4. XM_039082446.2 → XP_038938374.1  multiple epidermal growth factor-like domains protein 11 isoform X1

      UniProtKB/TrEMBL
      F1LVJ8
      Conserved Domains (3) summary
      pfam00053
      Location:275 → 320
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:189 → 234
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    5. XM_063266408.1 → XP_063122478.1  multiple epidermal growth factor-like domains protein 11 isoform X5

      Related
      ENSRNOP00000029099.5, ENSRNOT00000037941.7

    6. XM_039082453.2 → XP_038938381.1  multiple epidermal growth factor-like domains protein 11 isoform X7

      UniProtKB/TrEMBL
      F1LVJ8
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    7. XM_039082449.2 → XP_038938377.1  multiple epidermal growth factor-like domains protein 11 isoform X3

      UniProtKB/TrEMBL
      F1LVJ8, F1M370
      Related
      ENSRNOP00000110840.1, ENSRNOT00000149465.1
      Conserved Domains (3) summary
      pfam00053
      Location:275 → 320
      Laminin_EGF; Laminin EGF domain
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:189 → 234
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    8. XM_039082451.2 → XP_038938379.1  multiple epidermal growth factor-like domains protein 11 isoform X4

      UniProtKB/TrEMBL
      F1LVJ8
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    9. XM_039082452.2 → XP_038938380.1  multiple epidermal growth factor-like domains protein 11 isoform X6

      UniProtKB/TrEMBL
      F1LVJ8
      Related
      ENSRNOP00000054816.6, ENSRNOT00000058007.7
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    10. XM_039082461.2 → XP_038938389.1  multiple epidermal growth factor-like domains protein 11 isoform X14

      UniProtKB/TrEMBL
      F1M1F5
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    11. XM_039082463.2 → XP_038938391.1  multiple epidermal growth factor-like domains protein 11 isoform X16

      UniProtKB/TrEMBL
      F1M1F5
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    12. XM_063266410.1 → XP_063122480.1  multiple epidermal growth factor-like domains protein 11 isoform X8

    13. XM_039082460.2 → XP_038938388.1  multiple epidermal growth factor-like domains protein 11 isoform X13

      UniProtKB/TrEMBL
      F1LVJ8
      Related
      ENSRNOP00000072207.3, ENSRNOT00000082401.3
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    14. XM_039082457.2 → XP_038938385.1  multiple epidermal growth factor-like domains protein 11 isoform X10

      UniProtKB/TrEMBL
      F1LVJ8
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    15. XM_039082459.2 → XP_038938387.1  multiple epidermal growth factor-like domains protein 11 isoform X12

      Related
      ENSRNOP00000044316.6, ENSRNOT00000050649.8
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    16. XM_039082464.2 → XP_038938392.1  multiple epidermal growth factor-like domains protein 11 isoform X17

      Related
      ENSRNOP00000109919.1, ENSRNOT00000155392.1
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    17. XM_063266412.1 → XP_063122482.1  multiple epidermal growth factor-like domains protein 11 isoform X20

    18. XM_039082462.2 → XP_038938390.1  multiple epidermal growth factor-like domains protein 11 isoform X15

      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    19. XM_039082466.2 → XP_038938394.1  multiple epidermal growth factor-like domains protein 11 isoform X18

      UniProtKB/TrEMBL
      F1LVJ8
      Related
      ENSRNOP00000105993.1, ENSRNOT00000137343.1
      Conserved Domains (2) summary
      pfam07546
      Location:26 → 93
      EMI; EMI domain
      cl21504
      Location:275 → 320
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    20. XM_063266411.1 → XP_063122481.1  multiple epidermal growth factor-like domains protein 11 isoform X19

    21. XM_063266413.1 → XP_063122483.1  multiple epidermal growth factor-like domains protein 11 isoform X21

    22. XM_063266414.1 → XP_063122484.1  multiple epidermal growth factor-like domains protein 11 isoform X22

      Related
      ENSRNOP00000086502.2, ENSRNOT00000115064.2

    23. XM_063266415.1 → XP_063122485.1  multiple epidermal growth factor-like domains protein 11 isoform X23

    24. XM_039082454.2 → XP_038938382.1  multiple epidermal growth factor-like domains protein 11 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K2E0
      Related
      ENSRNOP00000103949.1, ENSRNOT00000156762.1
      Conserved Domains (1) summary
      cl21504
      Location:149 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RNA

    1. XR_005488258.2 RNA Sequence

    2. XR_005488259.2 RNA Sequence

    3. XR_010054415.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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