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    Rars2 arginyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rars2provided by RGD
    Official Full Name
    arginyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1305419
    See related
    EnsemblRapid:ENSRNOG00000008643 AllianceGenome:RGD:1305419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rarsl
    Summary
    Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 64.6), Kidney (RPKM 60.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rars2 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (53976808..54029715)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (49181517..49238664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (50075510..50127625)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350951 Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene uncharacterized LOC134478957 Neighboring gene akirin 2 Neighboring gene origin recognition complex, subunit 3 Neighboring gene solute carrier family 35 member A1 Neighboring gene cilia and flagella associated protein 206 Neighboring gene similar to human chromosome 6 open reading frame 163

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable arginine--tRNA ligase, mitochondrial
    Names
    arginyl-tRNA synthetase-like
    probable arginyl-tRNA synthetase, mitochondrial
    NP_001100113.1
    XP_006238048.1
    XP_038965363.1
    XP_038965364.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106643.2 → NP_001100113.1  probable arginine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001100113.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158744
      UniProtKB/TrEMBL
      A0A8I6G1M5, B0BNA3
      Related
      ENSRNOP00000111442.1, ENSRNOT00000143300.1
      Conserved Domains (3) summary
      cd00671
      Location:126 → 388
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      COG0018
      Location:30 → 578
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl12020
      Location:425 → 578
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      53976808..54029715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109436.2 → XP_038965364.1  probable arginine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG0018
      Location:30 → 346
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. XM_006237986.5 → XP_006238048.1  probable arginine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6G1M5, F7FFR1
      Related
      ENSRNOP00000011687.5, ENSRNOT00000011688.8
      Conserved Domains (3) summary
      cd00671
      Location:126 → 388
      ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
      COG0018
      Location:30 → 575
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cl12020
      Location:425 → 575
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    3. XM_039109435.2 → XP_038965363.1  probable arginine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG0018
      Location:2 → 403
      ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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