Flywch1 FLYWCH-type zinc finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flywch1provided by RGD
Official Full Name: FLYWCH-type zinc finger 1provided by RGD
Primary source: RGD:1309385
See related: EnsemblRapid:ENSRNOG00000004333 AllianceGenome:RGD:1309385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309385
Summary: Predicted to enable transcription coactivator binding activity and transcription corepressor activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear body; and pericentric heterochromatin. Predicted to be part of transcription regulator complex. Orthologous to human FLYWCH1 (FLYWCH-type zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 175.5), Adrenal (RPKM 87.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13279232..13298955, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (12774644..12794373, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13087925..13107833, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FLYWCH-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398792.1 → NP_001385721.1 FLYWCH-type zinc finger-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

F7FDF2

Related

ENSRNOP00000005879.7, ENSRNOT00000005879.9

Conserved Domains (3) summary

pfam04500
Location:231 → 289

FLYWCH; FLYWCH zinc finger domain

pfam15423
Location:1 → 83

FLYWCH_N; FLYWCH-type zinc finger-containing protein

pfam16662
Location:290 → 357

FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

13279232..13298955 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087076.2 → XP_038943004.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

A1L1L4, F7FDF2

Conserved Domains (3) summary

pfam04500
Location:231 → 289

FLYWCH; FLYWCH zinc finger domain

pfam15423
Location:1 → 83

FLYWCH_N; FLYWCH-type zinc finger-containing protein

pfam16662
Location:290 → 357

FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
XM_063269302.1 → XP_063125372.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_063269305.1 → XP_063125375.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_006245882.4 → XP_006245944.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006245944.1

UniProtKB/TrEMBL

A1L1L4, F7FDF2

Conserved Domains (3) summary

pfam04500
Location:231 → 289

FLYWCH; FLYWCH zinc finger domain

pfam15423
Location:1 → 83

FLYWCH_N; FLYWCH-type zinc finger-containing protein

pfam16662
Location:290 → 357

FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
XM_063269301.1 → XP_063125371.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_063269303.1 → XP_063125373.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_063269299.1 → XP_063125369.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_063269300.1 → XP_063125370.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2
XM_063269304.1 → XP_063125374.1 FLYWCH-type zinc finger-containing protein 1 isoform X1

UniProtKB/TrEMBL

F7FDF2