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    Asb12 ankyrin repeat and SOCS box-containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 503446, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Asb12provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 12provided by RGD
    Primary source
    RGD:1561142
    See related
    EnsemblRapid:ENSRNOG00000004197 AllianceGenome:RGD:1561142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 407.6) and Heart (RPKM 113.7) See more
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    Genomic context

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    See Asb12 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64338223..64487615, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60328325..60478031, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (64714337..64800662, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P1 like 2 Neighboring gene APC membrane recruitment protein 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A3-like Neighboring gene ribosomal protein SA, pseudogene 14 Neighboring gene profilin-2-like Neighboring gene zinc finger C4H2-type containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125221

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 12
    Names
    ankyrin repeat and SOCS box-containing protein 12
    NP_001032444.1
    XP_006257106.1
    XP_038955919.1
    XP_063136335.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037367.1 → NP_001032444.1  ankyrin repeat and SOCS box protein 12

      See identical proteins and their annotated locations for NP_001032444.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107911
      UniProtKB/TrEMBL
      F6RJR3, Q32Q00
      Conserved Domains (4) summary
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:175 → 199
      Ank; Ankyrin repeat
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001434359.1 → NP_001421288.1  ankyrin repeat and SOCS box protein 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F6RJR3, Q32Q00

    3. NM_001434360.1 → NP_001421289.1  ankyrin repeat and SOCS box protein 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F6RJR3, Q32Q00

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      64338223..64487615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099991.2 → XP_038955919.1  ankyrin repeat and SOCS box protein 12 isoform X1

      Conserved Domains (4) summary
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:175 → 199
      Ank; Ankyrin repeat
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063280265.1 → XP_063136335.1  ankyrin repeat and SOCS box protein 12 isoform X1

      UniProtKB/TrEMBL
      F6RJR3, Q32Q00
      Related
      ENSRNOP00000005663.4, ENSRNOT00000005663.8

    3. XM_006257044.5 → XP_006257106.1  ankyrin repeat and SOCS box protein 12 isoform X1

      Conserved Domains (4) summary
      sd00045
      Location:66 → 94
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:175 → 199
      Ank; Ankyrin repeat
      pfam07525
      Location:268 → 306
      SOCS_box; SOCS box
      pfam12796
      Location:68 → 159
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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