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    Rmc1 regulator of MON1-CCZ1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291784, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rmc1provided by RGD
    Official Full Name
    regulator of MON1-CCZ1provided by RGD
    Primary source
    RGD:1311805
    See related
    EnsemblRapid:ENSRNOG00000012597 AllianceGenome:RGD:1311805
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr98; C18orf8; RGD1311805
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in late endosome membrane. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 113.9), Lung (RPKM 112.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rmc1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3634604..3654519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3359848..3379764)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3597210..3617160)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 241 Neighboring gene uncharacterized LOC134482901 Neighboring gene RIO kinase 3 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene AKT interacting protein, pseudogene 1 Neighboring gene ankyrin repeat domain 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. Vaites LP, et al. Mol Cell Biol, 2018 Jan 1. PMID 29038162, Free PMC Article
    2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105615

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of MON1-CCZ1 complex
    Names
    WD repeat domain 98
    uncharacterized protein C18orf8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009638.1 → NP_001009638.1  regulator of MON1-CCZ1 complex

      See identical proteins and their annotated locations for NP_001009638.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087672
      UniProtKB/TrEMBL
      A6KNG9, Q5PPI8
      Related
      ENSRNOP00000017045.5, ENSRNOT00000017045.9
      Conserved Domains (1) summary
      pfam07035
      Location:475 → 632
      Mic1; Colon cancer-associated protein Mic1-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      3634604..3654519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096744.2 → XP_038952672.1  regulator of MON1-CCZ1 complex isoform X1

      Conserved Domains (1) summary
      pfam07035
      Location:318 → 475
      Mic1; Colon cancer-associated protein Mic1-like

    2. XM_039096746.2 → XP_038952674.1  regulator of MON1-CCZ1 complex isoform X3

      Conserved Domains (1) summary
      pfam07035
      Location:266 → 423
      Mic1; Colon cancer-associated protein Mic1-like

    3. XM_039096745.2 → XP_038952673.1  regulator of MON1-CCZ1 complex isoform X2

      Conserved Domains (1) summary
      pfam07035
      Location:269 → 426
      Mic1; Colon cancer-associated protein Mic1-like
    Nucleotide Protein Strain
    Heading Accession and Version

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