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    Kpna3 karyopherin subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361055, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kpna3provided by RGD
    Official Full Name
    karyopherin subunit alpha 3provided by RGD
    Primary source
    RGD:1311339
    See related
    EnsemblRapid:ENSRNOG00000014945 AllianceGenome:RGD:1311339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    importin
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be part of NLS-dependent protein nuclear import complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 88. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 393.2), Heart (RPKM 129.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kpna3 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (39712375..39786127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (35536310..35610066, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (41696356..41770112, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 11 Neighboring gene EBP like Neighboring gene ribosomal protein S20, pseudogene 1 Neighboring gene uncharacterized LOC120097005 Neighboring gene transfer RNA serine (anticodon AGA) 14 Neighboring gene uncharacterized LOC120097167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C/EBPα-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats. Chen WB, et al. Brain Res Bull, 2020 Nov. PMID 32814091
    2. Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock. Senol SP, et al. Inflamm Res, 2016 May. PMID 26875149
    3. Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth. Plant KE, et al. Pharmacogenet Genomics, 2006 Sep. PMID 16906019
    4. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. Kobayashi M, et al. J Biol Chem, 2002 Feb 22. PMID 11744694
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C/EBPalpha-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
      Title: C/EBPα-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
    2. The results suggest that an increase in the expression of PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and importin-alpha3 expression/activity participates in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation during endotoxemia and thus have a beneficial effect in septic shock treatment
      Title: Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-4
    Names
    importin subunit alpha-3
    karyopherin (importin) alpha 3
    karyopherin alpha 3
    predicted role in nuclear import

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014792.1 → NP_001014792.1  importin subunit alpha-4

      See identical proteins and their annotated locations for NP_001014792.1

      Status: PROVISIONAL

      Source sequence(s)
      AY779027
      UniProtKB/TrEMBL
      A0A8I5ZWC6, D3ZU98, Q56R18
      Related
      ENSRNOP00000032371.3, ENSRNOT00000034400.5
      Conserved Domains (2) summary
      COG5064
      Location:7 → 521
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:244 → 269
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      39712375..39786127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093504.1 → XP_038949432.1  importin subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWC6, A6K6B9
      Conserved Domains (2) summary
      COG5064
      Location:1 → 497
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:220 → 245
      ARM; armadillo repeat [structural motif]

    2. XM_006252127.4 → XP_006252189.1  importin subunit alpha-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWC6
      Related
      ENSRNOP00000084014.1, ENSRNOT00000106096.2
      Conserved Domains (4) summary
      COG5064
      Location:43 → 539
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:260 → 373
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:43 → 111
      IBB; Importin beta binding domain
      sd00043
      Location:262 → 287
      ARM; armadillo repeat [structural motif]

    3. XM_063274414.1 → XP_063130484.1  importin subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A6K6B9

    4. XM_039093503.1 → XP_038949431.1  importin subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWC6, A6K6B9
      Related
      ENSRNOP00000093015.1, ENSRNOT00000111588.2
      Conserved Domains (2) summary
      COG5064
      Location:1 → 497
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:220 → 245
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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