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    Ttc17 tetratricopeptide repeat domain 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311224, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttc17provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 17provided by RGD
    Primary source
    RGD:1305410
    See related
    EnsemblRapid:ENSRNOG00000010495 AllianceGenome:RGD:1305410
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in actin filament polymerization and cilium organization. Located in cytoplasm. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 129.9), Lung (RPKM 127.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc17 in Genome Data Viewer
    Location:
    3q31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (100718820..100829464, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (80263488..80374137, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (83198829..83306622, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene microRNA 129-2 Neighboring gene apoptosis inhibitor 5 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. Bontems F, et al. PLoS One, 2014. PMID 24475127, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 17
    Names
    TPR repeat protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107752.2 → NP_001101222.2  tetratricopeptide repeat protein 17 precursor

      See identical proteins and their annotated locations for NP_001101222.2

      Status: PROVISIONAL

      Source sequence(s)
      BC168714
      UniProtKB/Swiss-Prot
      B5DEL3, F1MA48
      Related
      ENSRNOP00000014088.6, ENSRNOT00000014088.9
      Conserved Domains (6) summary
      smart00028
      Location:689 → 718
      TPR; Tetratricopeptide repeats
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:1145 → 1175
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:1111 → 1173
      TPR_11; TPR repeat
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      100718820..100829464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591720.3 → XP_017447209.1  tetratricopeptide repeat protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIU8
      Related
      ENSRNOP00000090386.1, ENSRNOT00000099588.2

    2. XM_063283679.1 → XP_063139749.1  tetratricopeptide repeat protein 17 isoform X2

    3. XM_063283678.1 → XP_063139748.1  tetratricopeptide repeat protein 17 isoform X1

    4. XM_006234582.5 → XP_006234644.1  tetratricopeptide repeat protein 17 isoform X4

      Conserved Domains (5) summary
      smart00028
      Location:689 → 718
      TPR; Tetratricopeptide repeats
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:658 → 718
      TPR_11; TPR repeat
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain

    5. XM_039104915.2 → XP_038960843.1  tetratricopeptide repeat protein 17 isoform X6

      Conserved Domains (5) summary
      COG0457
      Location:563 → 718
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:621 → 647
      TPR; TPR repeat [structural motif]
      cd16269
      Location:379 → 390
      GBP_C; coiled coil [structural motif]
      pfam00515
      Location:297 → 328
      TPR_1; Tetratricopeptide repeat
      cl20817
      Location:329 → 410
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. XM_017591721.3 → XP_017447210.1  tetratricopeptide repeat protein 17 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKB8
      Related
      ENSRNOP00000077556.1, ENSRNOT00000110475.2

    RNA

    1. XR_005501867.2 RNA Sequence

    2. XR_005501866.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5DEL3.1 GenPept UniProtKB/Swiss-Prot:B5DEL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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