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    Usp30 ubiquitin specific peptidase 30 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp30provided by RGD
    Official Full Name
    ubiquitin specific peptidase 30provided by RGD
    Primary source
    RGD:1307949
    See related
    EnsemblRapid:ENSRNOG00000028556 AllianceGenome:RGD:1307949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in negative regulation of mitophagy. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and nucleus. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 69.8), Testes (RPKM 57.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp30 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48161905..48215878, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42501345..42555311, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48262663..48316580, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uracil-DNA glycosylase Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene legumain pseudogene Neighboring gene SV2 related protein Neighboring gene D-amino-acid oxidase Neighboring gene slingshot protein phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria. Cunningham CN, et al. Nat Cell Biol, 2015 Feb. PMID 25621951
    2. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Yue W, et al. Cell Res, 2014 Apr. PMID 24513856, Free PMC Article
    3. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM, et al. Genes Dev, 2015 May 15. PMID 25995186, Free PMC Article
    4. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179
    5. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K6-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 30
    Names
    deubiquitinating enzyme 30
    ub-specific protease 30
    ubiquitin specific protease 30
    ubiquitin thioesterase 30
    ubiquitin-specific-processing protease 30
    NP_001100623.1
    XP_017453842.1
    XP_038945451.1
    XP_063127467.1
    XP_063127468.1
    XP_063127469.1
    XP_063127470.1
    XP_063127471.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107153.1 → NP_001100623.1  ubiquitin carboxyl-terminal hydrolase 30

      See identical proteins and their annotated locations for NP_001100623.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/Swiss-Prot
      D3ZPG5
      UniProtKB/TrEMBL
      A0A8I5Y9C9
      Related
      ENSRNOP00000034698.4, ENSRNOT00000030891.6
      Conserved Domains (2) summary
      COG5560
      Location:69 → 265
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02662
      Location:69 → 500
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48161905..48215878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089523.2 → XP_038945451.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y9C9
      Conserved Domains (2) summary
      COG5560
      Location:38 → 234
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02662
      Location:38 → 469
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. XM_063271401.1 → XP_063127471.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y9C9

    3. XM_063271398.1 → XP_063127468.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9C9

    4. XM_063271400.1 → XP_063127470.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y9C9

    5. XM_017598353.3 → XP_017453842.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3K1, A0A8I5Y9C9
      Related
      ENSRNOP00000072669.2, ENSRNOT00000086231.3

    6. XM_063271397.1 → XP_063127467.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9C9

    7. XM_063271399.1 → XP_063127469.1  ubiquitin carboxyl-terminal hydrolase 30 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9C9
      Related
      ENSRNOP00000077164.2, ENSRNOT00000109684.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZPG5.1 GenPept UniProtKB/Swiss-Prot:D3ZPG5

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