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    Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683630, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mat2bprovided by RGD
    Official Full Name
    methionine adenosyltransferase 2 non-catalytic beta subunitprovided by RGD
    Primary source
    RGD:1593534
    See related
    EnsemblRapid:ENSRNOG00000003177 AllianceGenome:RGD:1593534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in nucleus. Predicted to be part of methionine adenosyltransferase complex. Orthologous to human MAT2B (methionine adenosyltransferase 2 non-catalytic beta subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 338.7), Brain (RPKM 338.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mat2b in Genome Data Viewer
    Location:
    10q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (25609202..25626694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (25106928..25122982, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (25832096..25848045, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene U4 spliceosomal RNA Neighboring gene hyaluronan-mediated motility receptor Neighboring gene NudC domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction. Li C, et al. Croat Med J, 2019 Oct 31. PMID 31686458, Free PMC Article
    2. Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups. He H, et al. Neuroreport, 2022 Mar 23. PMID 35287147
    3. Structure and function study of the complex that synthesizes S-adenosylmethionine. Murray B, et al. IUCrJ, 2014 Jul 1. PMID 25075345, Free PMC Article
    4. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). LeGros HL Jr, et al. J Biol Chem, 2000 Jan 28. PMID 10644686
    5. S-adenosylmethionine in liver health, injury, and cancer. Lu SC, et al. Physiol Rev, 2012 Oct. PMID 23073625, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
      Title: Dexmedetomidine alleviates the hypoxic-ischemic brain damage via miR-20a-5p/methionine adenosyltransferase 2B axis in rat pups.
    2. Investigated and confirmed protective effect of adipose-derived mesenchymal stem cells on miR-21-3p/methionine adenosyltransferase 2B (MAT2B) signal transduction in a rat ischemic brain injury model.
      Title: Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94725

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methionine adenosyltransferase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine adenosyltransferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methionine adenosyltransferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methionine adenosyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of methionine adenosyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of methionine adenosyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine adenosyltransferase 2 subunit beta
    Names
    MAT II beta
    methionine adenosyltransferase 2 beta subunit
    methionine adenosyltransferase 2B
    methionine adenosyltransferase II, beta
    NP_001037747.1
    XP_006246188.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044282.1 → NP_001037747.1  methionine adenosyltransferase 2 subunit beta

      See identical proteins and their annotated locations for NP_001037747.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085899
      UniProtKB/Swiss-Prot
      Q5U2R0
      UniProtKB/TrEMBL
      A0A8L2Q226, A6HDK5
      Related
      ENSRNOP00000004269.7, ENSRNOT00000004269.8
      Conserved Domains (1) summary
      cd05254
      Location:30 → 316
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      25609202..25626694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246126.5 → XP_006246188.1  methionine adenosyltransferase 2 subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006246188.1

      UniProtKB/TrEMBL
      A0A0G2JT30, A0A8I5ZYI5, A6HDK4
      Related
      ENSRNOP00000084010.1, ENSRNOT00000118093.2
      Conserved Domains (1) summary
      cd05254
      Location:19 → 305
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2R0.1 GenPept UniProtKB/Swiss-Prot:Q5U2R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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