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    Ggnbp2 gametogenetin binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360584, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggnbp2provided by RGD
    Official Full Name
    gametogenetin binding protein 2provided by RGD
    Primary source
    RGD:1302978
    See related
    EnsemblRapid:ENSRNOG00000027860 AllianceGenome:RGD:1302978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp403; Znf403
    Summary
    Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. Orthologous to human GGNBP2 (gametogenetin binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 236.9), Thymus (RPKM 195.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggnbp2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70208950..70240554, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69711527..69743134, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72156729..72188834, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene dehydrogenase/reductase 11 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. Ohbayashi T, et al. FEBS Lett, 2001 Nov 23. PMID 11728448
    2. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. Zhang J, et al. FEBS Lett, 2005 Jan 17. PMID 15642376
    3. Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Li S, et al. Biol Reprod, 2016 Feb. PMID 26764350, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gametogenetin-binding protein 2
    Names
    zinc finger protein 403

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004273.2 → NP_001004273.1  gametogenetin-binding protein 2

      See identical proteins and their annotated locations for NP_001004273.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6GVH5
      UniProtKB/TrEMBL
      A0A8L2QPK6
      Related
      ENSRNOP00000107424.1, ENSRNOT00000155459.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70208950..70240554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247048.5 → XP_006247110.1  gametogenetin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6D9

    2. XM_006247047.5 → XP_006247109.1  gametogenetin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6D9

    3. XM_006247052.5 → XP_006247114.1  gametogenetin-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8L2QPK6

    4. XM_006247051.5 → XP_006247113.1  gametogenetin-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QPK6

    5. XM_006247050.5 → XP_006247112.1  gametogenetin-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K6D9

    6. XM_006247049.5 → XP_006247111.1  gametogenetin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K6D9
      Related
      ENSRNOP00000049469.5, ENSRNOT00000042506.5

    7. XM_006247053.5 → XP_006247115.1  gametogenetin-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8L2QPK6
      Related
      ENSRNOP00000073773.3, ENSRNOT00000085728.3

    8. XM_006247054.5 → XP_006247116.1  gametogenetin-binding protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8L2QPK6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GVH5.1 GenPept UniProtKB/Swiss-Prot:Q6GVH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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