Dnajc13 DnaJ heat shock protein family (Hsp40) member C13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajc13provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member C13provided by RGD
Primary source: RGD:1308046
See related: EnsemblRapid:ENSRNOG00000011491 AllianceGenome:RGD:1308046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in endosome organization; receptor-mediated endocytosis; and regulation of intracellular transport. Predicted to be located in cytosol and early endosome membrane. Predicted to be part of WASH complex. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 402.7), Thymus (RPKM 145.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 58

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (113646573..113756104, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (104767785..104877317, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (112697907..112830445, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suggest a model in which the localization of RME-8 to endosomal compartments is spatially mediated by PI(3)P binding and temporally regulated by MTMR2 activity
Title: Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2.
RME-8 functions in intracellular trafficking and provides the first evidence of a functional role for a DnaJ domain-bearing co-chaperone on endosomes
Title: The DnaJ-domain protein RME-8 functions in endosomal trafficking.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of WASH complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 13

Names: DnaJ (Hsp40) homolog, subfamily C, member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108776.3 → NP_001102246.2 dnaJ homolog subfamily C member 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AX46

Related

ENSRNOP00000098001.1, ENSRNOT00000117009.2

Conserved Domains (2) summary

pfam00226
Location:1301 → 1354

DnaJ; DnaJ domain

pfam14237
Location:976 → 1026

DUF4339; Domain of unknown function (DUF4339)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

113646573..113756104 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265807.1 → XP_063121877.1 dnaJ homolog subfamily C member 13 isoform X2

Related

ENSRNOP00000099858.1, ENSRNOT00000164659.1
XM_039081778.2 → XP_038937706.1 dnaJ homolog subfamily C member 13 isoform X1

UniProtKB/TrEMBL

A0A8I6AX46

Related

ENSRNOP00000091506.2, ENSRNOT00000096102.2

Conserved Domains (2) summary

pfam00226
Location:1309 → 1362

DnaJ; DnaJ domain

pfam14237
Location:984 → 1034

DUF4339; Domain of unknown function (DUF4339)
XM_063265808.1 → XP_063121878.1 dnaJ homolog subfamily C member 13 isoform X3