Mfap4 microfibril associated protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mfap4provided by RGD
Full Name: microfibril associated protein 4provided by RGD
Primary source: RGD:1307841
See related: EnsemblRapid:ENSRNOG00000045683 AllianceGenome:RGD:1307841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Magp-36
Summary: Predicted to be involved in elastic fiber assembly; regulation of collagen metabolic process; and response to UV. Predicted to be located in several cellular components, including collagen-containing extracellular matrix; elastic fiber; and microfibril. Orthologous to human MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 5189.4), Uterus (RPKM 592.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46666552..46669613)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46167158..46170176)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47765463..47768484)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

differential gene expression of microfibril-associated glycoprotein (MAGP-36); MAGP-36 was expressed highly in sites rich in elastic fibers - aorta, skin & esophagus, but it was also expressed highly in other sites containing no elastic fibers.
Title: Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129756 (e-PCR)
- UniSTS:213049

UniSTS:469818 (e-PCR)
- UniSTS:469818

Mapk7 (e-PCR), detects polymorphism
- UniSTS:469818

RH141658 (e-PCR)
- UniSTS:223651

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in UV protection	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in elastic fiber	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in microfibril	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microfibril-associated glycoprotein 4

Names: microfibril-associated glycoprotein 4-like; microfibrillar-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034124.2 → NP_001029296.2 microfibril-associated glycoprotein 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HF80, G3V6A9, Q497C9

Conserved Domains (1) summary

cd00087
Location:38 → 256

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46666552..46669613

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246560.5 → XP_006246622.1 microfibril-associated glycoprotein 4 isoform X1

See identical proteins and their annotated locations for XP_006246622.1

UniProtKB/TrEMBL

D4A7W8, G3V6A9, Q497C9

Related

ENSRNOP00000054690.5, ENSRNOT00000057880.6

Conserved Domains (1) summary

cd00087
Location:38 → 280

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...