Ext2 exostosin glycosyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ext2provided by RGD
Official Full Name: exostosin glycosyltransferase 2provided by RGD
Primary source: RGD:1307707
See related: EnsemblRapid:ENSRNOG00000008944 AllianceGenome:RGD:1307707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable UDP-glycosyltransferase activity and protein dimerization activity. Predicted to be involved in glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and ossification. Predicted to act upstream of or within with a positive effect on gene expression; protein N-linked glycosylation; and sulfation. Predicted to act upstream of or within several processes, including heparin biosynthetic process; multicellular organismal-level water homeostasis; and skeletal system development. Predicted to be located in endoplasmic reticulum. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in Golgi apparatus. Orthologous to human EXT2 (exostosin glycosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 195.8), Kidney (RPKM 157.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (100120776..100253424, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (79665414..79798077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (82602784..82734557, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ext2 gene is involved in heparan sulfate proteoglycans metabolism.
Title: Expression of Ext1, Ext2, and heparanase genes in brain of senescence-accelerated OXYS rats in early ontogenesis and during development of neurodegenerative changes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH128252 (e-PCR)
- UniSTS:211560

AU025621 (e-PCR)
- UniSTS:115081

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
NOT enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fluid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heparin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in polysaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect sulfation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of UDP-N-acetylglucosamine transferase complex	ISO Inferred from Sequence Orthology more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exostosin-2

Names: exostoses (multiple) 2; exostosin 2

NP_001101221.1

EC 2.4.1.224

NP_001386435.1

EC 2.4.1.224

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107751.2 → NP_001101221.1 exostosin-2 isoform 2

See identical proteins and their annotated locations for NP_001101221.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNJ4, B2RYE4, E9PTT2

Related

ENSRNOP00000012161.5, ENSRNOT00000012161.9

Conserved Domains (2) summary

pfam03016
Location:100 → 380

Exostosin; Exostosin family

pfam09258
Location:456 → 642

Glyco_transf_64; Glycosyl transferase family 64 domain
NM_001399506.1 → NP_001386435.1 exostosin-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2KAH7

Related

ENSRNOP00000075401.2, ENSRNOT00000083743.3

Conserved Domains (2) summary

pfam03016
Location:100 → 380

Exostosin; Exostosin family

pfam09258
Location:456 → 697

Glyco_transf_64; Glycosyl transferase family 64 domain