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    Timm10 translocase of inner mitochondrial membrane 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64464, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Timm10provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 10provided by RGD
    Primary source
    RGD:621741
    See related
    EnsemblRapid:ENSRNOG00000007883 AllianceGenome:RGD:621741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim10
    Summary
    Predicted to enable membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human TIMM10 (translocase of inner mitochondrial membrane 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 295.5), Muscle (RPKM 173.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Timm10 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90315048..90318613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69908397..69911943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72226563..72230087)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 6 Neighboring gene smoothelin-like 1 Neighboring gene uncharacterized LOC120101592 Neighboring gene solute carrier family 43 member 1 Neighboring gene uncharacterized LOC102554396 Neighboring gene reticulon 4 receptor-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane. Adrian GS, et al. Mol Cell Biol, 1986 Feb. PMID 3023860, Free PMC Article
    2. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Webb CT, et al. Mol Cell, 2006 Jan 6. PMID 16387659
    3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
    4. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim10
    Names
    small zinc finger-like protein
    translocase of inner mitochondrial membrane 10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431423.1 → NP_001418352.1  mitochondrial import inner membrane translocase subunit Tim10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8

    2. NM_001431424.1 → NP_001418353.1  mitochondrial import inner membrane translocase subunit Tim10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8

    3. NM_172074.4 → NP_742071.1  mitochondrial import inner membrane translocase subunit Tim10

      See identical proteins and their annotated locations for NP_742071.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P62074, Q5BKD3
      UniProtKB/TrEMBL
      A6HMR8
      Conserved Domains (1) summary
      pfam02953
      Location:7 → 69
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90315048..90318613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234473.5 → XP_006234535.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      Conserved Domains (1) summary
      pfam02953
      Location:7 → 69
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. XM_006234474.5 → XP_006234536.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      Related
      ENSRNOP00000010619.3, ENSRNOT00000010619.6
      Conserved Domains (1) summary
      pfam02953
      Location:7 → 69
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62074.1 GenPept UniProtKB/Swiss-Prot:P62074

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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