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    Dmd dystrophin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dmdprovided by RGD
    Official Full Name
    dystrophinprovided by RGD
    Primary source
    RGD:2507
    See related
    EnsemblRapid:ENSRNOG00000046366 AllianceGenome:RGD:2507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DNADMD1
    Summary
    Enables several functions, including PDZ domain binding activity; integrin binding activity; and lamin binding activity. Involved in several processes, including nervous system development; regulation of neuron differentiation; and response to denervation involved in regulation of muscle adaptation. Located in several cellular components, including mitochondrial membrane; neurofilament; and secretory vesicle. Part of dystrophin-associated glycoprotein complex. Used to study Duchenne muscular dystrophy; brain edema; and dilated cardiomyopathy. Biomarker of muscular atrophy; retinal degeneration; and status epilepticus. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (dystrophin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 256.1), Muscle (RPKM 255.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dmd in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    84
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (51070098..53437845)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (47272324..49504219)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (51149358..53519271)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene centrin-2-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene 60S ribosomal protein L5-like Neighboring gene A/G-specific adenine DNA glycosylase-like Neighboring gene histone H2A.V-like Neighboring gene testis-specific gene A8 protein-like Neighboring gene BCL2 interacting protein 3 like, pseudogene 1 Neighboring gene high mobility group protein B4-like Neighboring gene uncharacterized LOC120099238 Neighboring gene ferritin, heavy polypeptide-like 17, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dystroglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    enables vinculin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within connective tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of blood-nerve barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of glial blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myotube cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-cysteine S-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleus localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within olfactory nerve structural organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of muscle system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to denervation involved in regulation of muscle adaptation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striated muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_positive_effect synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in astrocyte projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-substrate junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystrophin-associated glycoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of dystrophin-associated glycoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in matrix side of mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane bounded cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dystrophin
    Names
    apodystrophin-3
    apodystrophin-I
    dystrophin, muscular dystrophy
    dystrophin-related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005244.2NP_001005244.1  dystrophin isoform Dp71ab

      See identical proteins and their annotated locations for NP_001005244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Dp71ab) lacks an exon in the 3' coding region, resulting in a frameshift, as compared to variant Dp71a. The encoded isoform Dp71ab has a longer and distinct C-terminus, as compared to isoform Dp71a.
      Source sequence(s)
      AY326948
      UniProtKB/TrEMBL
      A0A0G2K2Z6, F1LN35, Q7TPH3
      Conserved Domains (4) summary
      cd02334
      Location:243291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:21139
      EF-hand_2; EF hand
      pfam09069
      Location:143234
      EF-hand_3; EF-hand
      pfam16769
      Location:407600
      MCM3AP_GANP; MCM3AP domain of GANP
    2. NM_001005246.1NP_001005246.1  dystrophin isoform Dp71c

      See identical proteins and their annotated locations for NP_001005246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Dp71c) lacks an in-frame segment including three exons in the coding region, as compared to variant Dp71a. The encoded isoform 71c lacks an internal segment, as compared to isoform Dp71a.
      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0F7CRZ7, Q7TPH2
      Conserved Domains (3) summary
      cd02334
      Location:243291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam16769
      Location:358493
      MCM3AP_GANP; MCM3AP domain of GANP
      cd16246
      Location:57218
      EFh_DMD; EF-hand-like motif found in dystrophin
    3. NM_001370876.1NP_001357805.1  dystrophin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      F1M705, P11530
      Related
      ENSRNOP00000029969.6, ENSRNOT00000035692.8
      Conserved Domains (7) summary
      COG5069
      Location:12232
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:345559
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:30513080
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:33033351
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR02168
      Location:11272060
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16246
      Location:31173278
      EFh_DMD; EF-hand-like motif found in dystrophin
      cl02488
      Location:561781
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. NM_012698.3NP_036830.2  dystrophin isoform Dp71a

      See identical proteins and their annotated locations for NP_036830.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Dp71a) consists of 17 exons and encodes isoform Dp71a.
      Source sequence(s)
      AY326947
      UniProtKB/TrEMBL
      F5CC78, Q7TPH4
      Conserved Domains (3) summary
      COG1196
      Location:354524
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:243291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:57218
      EFh_DMD; EF-hand-like motif found in dystrophin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      51070098..53437845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279795.1XP_063135865.1  dystrophin isoform X2

      Related
      ENSRNOP00000111691.1, ENSRNOT00000125414.1
    2. XM_063279798.1XP_063135868.1  dystrophin isoform X7

    3. XM_063279800.1XP_063135870.1  dystrophin isoform X9

    4. XM_063279801.1XP_063135871.1  dystrophin isoform X10

      Related
      ENSRNOP00000074105.2, ENSRNOT00000091467.3
    5. XM_063279797.1XP_063135867.1  dystrophin isoform X6

    6. XM_017601909.3XP_017457398.1  dystrophin isoform X3

    7. XM_063279794.1XP_063135864.1  dystrophin isoform X1

    8. XM_063279799.1XP_063135869.1  dystrophin isoform X8

    9. XM_063279796.1XP_063135866.1  dystrophin isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKZ8
      Related
      ENSRNOP00000095060.1, ENSRNOT00000094721.2
    10. XM_039099484.2XP_038955412.1  dystrophin isoform X5

      Conserved Domains (9) summary
      cd00176
      Location:309523
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:30153044
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:32673315
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR02168
      Location:10912024
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd16246
      Location:30813242
      EFh_DMD; EF-hand-like motif found in dystrophin
      pfam00435
      Location:28902996
      Spectrin; Spectrin repeat
      cd21233
      Location:100210
      CH_DMD_rpt2; second calponin homology (CH) domain found in dystrophin and similar proteins
      cl00030
      Location:1785
      CH_SF; calponin homology (CH) domain superfamily
      cl02488
      Location:525745
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    11. XM_063279802.1XP_063135872.1  dystrophin isoform X11

    12. XM_063279803.1XP_063135873.1  dystrophin isoform X12

    13. XM_063279804.1XP_063135874.1  dystrophin isoform X13

    14. XM_063279805.1XP_063135875.1  dystrophin isoform X14

    15. XM_008773252.4XP_008771474.1  dystrophin isoform X15

      UniProtKB/TrEMBL
      A0A0G2K2Z6, A0A8J8Y3R2
      Related
      ENSRNOP00000032859.5, ENSRNOT00000034372.8
      Conserved Domains (4) summary
      cd02334
      Location:243291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:21139
      EF-hand_2; EF hand
      pfam09069
      Location:143234
      EF-hand_3; EF-hand
      pfam16769
      Location:420613
      MCM3AP_GANP; MCM3AP domain of GANP
    16. XM_008773253.4XP_008771475.1  dystrophin isoform X16

      See identical proteins and their annotated locations for XP_008771475.1

      UniProtKB/TrEMBL
      F5CC78
      Conserved Domains (3) summary
      COG1196
      Location:367537
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02334
      Location:243291
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16246
      Location:57218
      EFh_DMD; EF-hand-like motif found in dystrophin