Npy5r neuropeptide Y receptor Y5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npy5rprovided by RGD
Official Full Name: neuropeptide Y receptor Y5provided by RGD
Primary source: RGD:3199
See related: EnsemblRapid:ENSRNOG00000014172 AllianceGenome:RGD:3199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NPYR5
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Predicted to be located in membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; neuron projection; and presynapse. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 14.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (27822055..27830012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (23055427..23063384)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (24796685..24805730)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Title: Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
long-term over-expression of NPY in paraventricular nucleus contributes to the establishment of adipose tissue insulin resistance, at least partly via the Y5 receptor
Title: Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor.
Our results showed the altered expression of NPY, Y1R and Y2R but not Y5R in hippocampus and temporal lobe cortex of tremor rat brain.
Title: Altered expression of neuropeptide Y, Y1 and Y2 receptors, but not Y5 receptor, within hippocampus and temporal lobe cortex of tremor rats.
Y5R does no tparticipate in the anorectic response to phenylpropanolamine.
Title: The identification of neuropeptide Y receptor subtype involved in phenylpropanolamine-induced increase in oxidative stress and appetite suppression.
results suggest that while signals mediated through NPY Y1 receptors play a modest role in reinstatement, activation of Y5 receptors has a critical function in food deprivation-induced reinstatement of heroin-seeking behavior.
Title: A role for neuropeptide Y Y5 but not the Y1-receptor subtype in food deprivation-induced reinstatement of heroin seeking in the rat.
the inhibition of central Y5 neurotransmission resulted in activation of thyroid axis during fasting suggesting that NPY-Y5 receptors contribute to fasting-induced TSH and TH suppression
Title: Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat.
NPY and Y5R expression increased by more than 130-fold and decreased by 28-fold, respectively, in old bone marrow cells as compared to young bone marrow cells.
Title: Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells.
These results suggest that in addition to regulating feeding behaviour, the Y5 receptor subtype may have previously unrecognised roles in the control of nesting behaviour during lactation with subsequent effects on litter growth rates.
Title: Regulation of maternal food intake and mother-pup interactions by the Y5 receptor.
Y5 receptors mediate inhibitory effects of NPY in kindling and display anticonvulsant rather then antiepileptogenic effects upon agonist stimulation
Title: Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats.
via a specific Y-1R/Y-5R interplay, NPY acts as a neuroimmune co-transmitter in vivo.
Title: NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

PMC123072P1 (e-PCR)
- UniSTS:270434

RH94803 (e-PCR)
- UniSTS:120049

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide Y receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pancreatic polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide YY receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac left ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generation of ovulation cycle rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic signaling via neuropeptide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuropeptide Y receptor type 5

Names: NPY-Y5 receptor; NPY5-R; NPYY5-R; Neuropeptide Y5 receptor; Y5 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012869.2 → NP_037001.1 neuropeptide Y receptor type 5

See identical proteins and their annotated locations for NP_037001.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

P70586, Q63634

UniProtKB/TrEMBL

A6KFL9

Related

ENSRNOP00000089710.1, ENSRNOT00000099301.2

Conserved Domains (2) summary

pfam00001
Location:58 → 424

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 170

7tm_4; Olfactory receptor