Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugt2b35provided by RGD
Official Full Name: UDP glucuronosyltransferase 2 family, polypeptide B35provided by RGD
Primary source: RGD:620895
See related: EnsemblRapid:ENSRNOG00000001980 AllianceGenome:RGD:620895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ugt2b4; Ugt2b12; Ugt2b15; Ugt2b36
Summary: Predicted to enable glucuronosyltransferase activity. Involved in cellular glucuronidation and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 3450.6) and Kidney (RPKM 2390.8) See more
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Genomic context

Location:: 14p21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (21208389..21245893)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20853441..20891039)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22553633..22591461)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that gonadotropins transiently stimulate Ugt2b15 expression and activity in granulosa cells of pre-ovulatory follicles as they undergo ovulation; Ugt2b15 mRNA levels appear to be regulated by signal transduction involving progesterone receptors and vitamin D receptors.
Title: Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular glucuronidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 2B15

Names: UDP glucuronosyltransferase 2 family, polypeptide B15; UDP glucuronosyltransferase 2 family, polypeptide B36; UDP glycosyltransferase 2 family, polypeptide B4; UDP-glucuronosyltransferase 2B12; UDP-glucuronosyltransferase 2B36; UDP-glucuronosyltransferase 2B4; UDPGT 2B12; UDPGT 2B15; UDPGT 2B36; UDPGT 2B4

NP_001004271.1

EC 2.4.1.17

XP_008768282.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004271.1 → NP_001004271.1 UDP-glucuronosyltransferase 2B15 precursor

See identical proteins and their annotated locations for NP_001004271.1

Status: PROVISIONAL

Source sequence(s)

BC078782

UniProtKB/Swiss-Prot

P36511

UniProtKB/TrEMBL

F7FMW8, Q68G19

Related

ENSRNOP00000002712.3, ENSRNOT00000002712.7

Conserved Domains (2) summary

PHA03392
Location:270 → 489

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:24 → 527

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

21208389..21245893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770060.4 → XP_008768282.1 UDP-glucuronosyltransferase 2B15 isoform X1

Conserved Domains (2) summary

pfam00201
Location:24 → 336

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

cl10013
Location:45 → 334

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...