Miox myo-inositol oxygenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mioxprovided by RGD
Official Full Name: myo-inositol oxygenaseprovided by RGD
Primary source: RGD:628739
See related: EnsemblRapid:ENSRNOG00000008694 AllianceGenome:RGD:628739
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RSOR; Aldrl6
Summary: Enables NADP binding activity. Predicted to be involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. Orthologous to human MIOX (myo-inositol oxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 5905.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122284660..122287158)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120405031..120407529)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130308707..130311205)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Miox expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of Miox activity is related to phosphorylation of serine/threonine residues.
Title: Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
increased expression of MIOX in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy
Title: Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy.
Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein.
Title: Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney.

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General gene information

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Markers

RH131425 (e-PCR)
- UniSTS:214708

AW108536 (e-PCR)
- UniSTS:209132

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables aldo-keto reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables ferric iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol oxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol oxygenase activity	IEA Inferred from Electronic Annotation more info
enables inositol oxygenase activity	ISO Inferred from Sequence Orthology more info
enables inositol oxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inositol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in inositol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inositol catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inositol oxygenase

Names: MI oxygenase; aldehyde reductase (aldose reductase) like 6; aldehyde reductase-like 6; kidney-specific protein 32; renal-specific oxido-reductase; renal-specific oxidoreductase

NP_665714.2

EC 1.13.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.