Chkb choline kinase beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chkbprovided by RGD
Official Full Name: choline kinase betaprovided by RGD
Primary source: RGD:61826
See related: EnsemblRapid:ENSRNOG00000011404 AllianceGenome:RGD:61826
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chkl; Chetk
Summary: Enables choline kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within muscle organ development and phosphatidylcholine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 120.4), Thymus (RPKM 109.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122380592..122385102, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120500960..120504359, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130404818..130408813, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046862 (e-PCR)
- UniSTS:115925

Chetk (e-PCR)
- UniSTS:261874

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables choline kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables choline kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables choline kinase activity	ISO Inferred from Sequence Orthology more info
enables choline kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: choline/ethanolamine kinase

Names: CK; CKB; CKEKB; EK; choline/ethanolamine kinase beta; ethanolamine kinase

NP_058873.1

EC 2.7.1.32

EC 2.7.1.82

XP_006242243.2

EC 2.7.1.32

EC 2.7.1.82

XP_038934502.1

EC 2.7.1.32

EC 2.7.1.82

XP_038934504.1

EC 2.7.1.32

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017177.1 → NP_058873.1 choline/ethanolamine kinase

See identical proteins and their annotated locations for NP_058873.1

Status: PROVISIONAL

Source sequence(s)

AB006607

UniProtKB/Swiss-Prot

O54783

UniProtKB/TrEMBL

A6K7M9

Related

ENSRNOP00000015374.1, ENSRNOT00000015374.4

Conserved Domains (1) summary

cd05156
Location:73 → 385

ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122380592..122385102 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242181.5 → XP_006242243.2 choline/ethanolamine kinase isoform X1

Conserved Domains (1) summary

cl21453
Location:162 → 399

PKc_like; Protein Kinases, catalytic domain
XM_039078574.2 → XP_038934502.1 choline/ethanolamine kinase isoform X2

Conserved Domains (1) summary

cl21453
Location:69 → 306

PKc_like; Protein Kinases, catalytic domain
XM_039078576.2 → XP_038934504.1 choline/ethanolamine kinase isoform X3

Conserved Domains (1) summary

cl21453
Location:24 → 261

PKc_like; Protein Kinases, catalytic domain