U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cryba4 crystallin, beta A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64348, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cryba4provided by RGD
    Official Full Name
    crystallin, beta A4provided by RGD
    Primary source
    RGD:61962
    See related
    EnsemblRapid:ENSRNOG00000049770 AllianceGenome:RGD:61962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    A structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Biomarker of cataract. Human ortholog(s) of this gene implicated in cataract 23. Orthologous to human CRYBA4 (crystallin beta A4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 8.9), Kidney (RPKM 8.8) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cryba4 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (50039148..50053636)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44378734..44393226)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50407843..50414434)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tuftelin interacting protein 11 Neighboring gene SRR1 domain containing Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene crystallin, beta B1 Neighboring gene uncharacterized LOC134481212 Neighboring gene myocardial infarction associated transcript Neighboring gene uncharacterized LOC120095864

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystallin proteins in lenses of hereditary cataractous rat, ICR/f. Takeuchi N, et al. Biol Pharm Bull, 2000 Mar. PMID 10726880
    2. CRYBA4, a novel human cataract gene, is also involved in microphthalmia. Billingsley G, et al. Am J Hum Genet, 2006 Oct. PMID 16960806, Free PMC Article
    3. Biochemical characterization of G64W mutant of acidic beta-crystallin 4. Li W, et al. Exp Eye Res, 2019 Sep. PMID 31254514
    4. Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. David LL, et al. FEBS Lett, 1993 Jun 21. PMID 8405363
    5. Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Lampi KJ, et al. Invest Ophthalmol Vis Sci, 2002 Jan. PMID 11773034

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-crystallin A4
    Names
    beta-A4 crystallin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031689.1 → NP_113877.1  beta-crystallin A4

      See identical proteins and their annotated locations for NP_113877.1

      Status: PROVISIONAL

      Source sequence(s)
      AF013247
      UniProtKB/Swiss-Prot
      P56374
      UniProtKB/TrEMBL
      A6J267
      Related
      ENSRNOP00000066572.1, ENSRNOT00000073763.3
      Conserved Domains (1) summary
      pfam00030
      Location:13 → 97
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      50039148..50053636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089722.2 → XP_038945650.1  beta-crystallin A4 isoform X1

      UniProtKB/Swiss-Prot
      P56374
      UniProtKB/TrEMBL
      A6J267
      Conserved Domains (1) summary
      pfam00030
      Location:13 → 97
      Crystall; Beta/Gamma crystallin

    2. XM_039089723.1 → XP_038945651.1  beta-crystallin A4 isoform X2

      Conserved Domains (1) summary
      pfam00030
      Location:8 → 92
      Crystall; Beta/Gamma crystallin

    3. XM_017598447.2 → XP_017453936.1  beta-crystallin A4 isoform X1

      UniProtKB/Swiss-Prot
      P56374
      UniProtKB/TrEMBL
      A6J267
      Conserved Domains (1) summary
      pfam00030
      Location:13 → 97
      Crystall; Beta/Gamma crystallin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56374.2 GenPept UniProtKB/Swiss-Prot:P56374

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools