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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001113460.2 → NP_001106931.1 tyrosine-protein kinase Tec isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
- Source sequence(s)
-
AC099698, AK139329, AK168460, CJ047828
- Consensus CDS
-
CCDS51516.1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Related
- ENSMUSP00000071836.7, ENSMUST00000071944.13
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
NM_001113461.2 → NP_001106932.1 tyrosine-protein kinase Tec isoform b
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter than isoform a.
- Source sequence(s)
-
AC099698, AK168452, AK168460, CJ047828
- Consensus CDS
-
CCDS51515.1
- UniProtKB/TrEMBL
- Q3TH41, Q8CFK4
- Related
- ENSMUSP00000073509.7, ENSMUST00000073843.13
- Conserved Domains (6) summary
-
- cd10396
Location:220 → 324
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:342 → 601
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
- pfam00169
Location:5 → 111
- PH; PH domain
- pfam07714
Location:347 → 596
- Pkinase_Tyr; Protein tyrosine kinase
- cl17036
Location:182 → 223
- SH3; Src Homology 3 domain superfamily
-
NM_001113464.2 → NP_001106935.1 tyrosine-protein kinase Tec isoform a
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
- Source sequence(s)
-
AC099698, AK139329, CJ047828
- Consensus CDS
-
CCDS51516.1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Related
- ENSMUSP00000109224.2, ENSMUST00000113594.8
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
NM_013689.5 → NP_038717.2 tyrosine-protein kinase Tec isoform c
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate in-frame exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c, which is shorter and has a distinct N-terminus, compared to isoform a.
- Source sequence(s)
-
AC099698, AK133418, AK139329
- UniProtKB/TrEMBL
-
Q3TH41
- Conserved Domains (5) summary
-
- cd10396
Location:139 → 243
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd05114
Location:261 → 520
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
- pfam07714
Location:266 → 515
- Pkinase_Tyr; Protein tyrosine kinase
- cl17036
Location:101 → 142
- SH3; Src Homology 3 domain superfamily
- cl17171
Location:11 → 67
- PH-like; Pleckstrin homology-like domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000071.7 Reference GRCm39 C57BL/6J
- Range
-
72913061..73025997 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006503846.5 → XP_006503909.1 tyrosine-protein kinase Tec isoform X1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
XM_011240719.4 → XP_011239021.1 tyrosine-protein kinase Tec isoform X1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
XM_006503845.5 → XP_006503908.1 tyrosine-protein kinase Tec isoform X1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
XM_011240718.3 → XP_011239020.1 tyrosine-protein kinase Tec isoform X1
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- UniProtKB/TrEMBL
-
Q3U436
- Conserved Domains (4) summary
-
- cd10396
Location:239 → 346
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:182 → 236
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd01238
Location:7 → 148
- PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
- cd05114
Location:364 → 623
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
-
XM_006503848.5 → XP_006503911.1 tyrosine-protein kinase Tec isoform X3
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- Conserved Domains (4) summary
-
- cd10396
Location:158 → 265
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:101 → 155
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd05114
Location:283 → 542
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
- cl17171
Location:11 → 67
- PH-like; Pleckstrin homology-like domain
-
XM_006503847.2 → XP_006503910.1 tyrosine-protein kinase Tec isoform X2
- UniProtKB/Swiss-Prot
- P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3
- Conserved Domains (4) summary
-
- cd10396
Location:206 → 313
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:149 → 203
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd05114
Location:331 → 590
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase
- cl17171
Location:9 → 115
- PH-like; Pleckstrin homology-like domain
-
XM_036164992.1 → XP_036020885.1 tyrosine-protein kinase Tec isoform X4
- UniProtKB/TrEMBL
-
I6L9F0
- Conserved Domains (3) summary
-
- cd10396
Location:54 → 161
- SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
- cd11905
Location:1 → 51
- SH3_Tec; Src Homology 3 domain of Tec (Tyrosine kinase expressed in hepatocellular carcinoma)
- cd05114
Location:179 → 438
- PTKc_Tec_Rlk; Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase