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    Ccdc122 coiled-coil domain containing 122 [ Mus musculus (house mouse) ]

    Gene ID: 108811, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc122provided by MGI
    Official Full Name
    coiled-coil domain containing 122provided by MGI
    Primary source
    MGI:MGI:1918358
    See related
    Ensembl:ENSMUSG00000034795 AllianceGenome:MGI:1918358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933415L06Rik
    Summary
    Orthologous to human CCDC122 (coiled-coil domain containing 122). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 4.3), bladder adult (RPKM 2.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc122 in Genome Data Viewer
    Location:
    14 D3; 14 40.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77274212..77349703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77036772..77112263)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37199 Neighboring gene STARR-seq mESC enhancer starr_37200 Neighboring gene predicted gene, 30365 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene laccase domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene ecto-NOX disulfide-thiol exchanger 1 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106895

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 122

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310648.1 → NP_001297577.1  coiled-coil domain-containing protein 122 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK077161, AW554226, BC145455
      UniProtKB/Swiss-Prot
      Q8BVN0
      Conserved Domains (1) summary
      pfam13166
      Location:18 → 208
      AAA_13; AAA domain

    2. NM_001310649.1 → NP_001297578.1  coiled-coil domain-containing protein 122 isoform 3

      See identical proteins and their annotated locations for NP_001297578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 5' and central coding regions, compared to variant 1. The encoded isoform (3) is shorter, but has the same N- and C-termini, as isoform 1.
      Source sequence(s)
      AK077161, AW554226, BC096577
      Consensus CDS
      CCDS79346.1
      UniProtKB/TrEMBL
      Q4VA24
      Related
      ENSMUSP00000093285.5, ENSMUST00000095625.11
      Conserved Domains (1) summary
      pfam07851
      Location:28 → 104
      TMPIT; TMPIT-like protein

    3. NM_175369.4 → NP_780578.1  coiled-coil domain-containing protein 122 isoform 1

      See identical proteins and their annotated locations for NP_780578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK077161, AW554226
      Consensus CDS
      CCDS27288.1
      UniProtKB/Swiss-Prot
      B2RSJ0, Q8BVN0
      Related
      ENSMUSP00000036369.4, ENSMUST00000048208.10
      Conserved Domains (1) summary
      TIGR02169
      Location:15 → 288
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      77274212..77349703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVN0.1 GenPept UniProtKB/Swiss-Prot:Q8BVN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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