Nudt7 nudix hydrolase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt7provided by MGI
Official Full Name: nudix hydrolase 7provided by MGI
Primary source: MGI:MGI:1914778
See related: Ensembl:ENSMUSG00000031767 AllianceGenome:MGI:1914778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300007B24Rik; 2210404C19Rik
Summary: Enables coenzyme A diphosphatase activity; magnesium ion binding activity; and snoRNA binding activity. Involved in nucleoside phosphate catabolic process. Acts upstream of or within brown fat cell differentiation. Located in peroxisome. Orthologous to human NUDT7 (nudix hydrolase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 27.8), subcutaneous fat pad adult (RPKM 6.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 60.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (114860314..114881471)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (114133574..114154731)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice.
Title: Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice.
NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
Title: NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet.
The modulation of Nudt7 activity could contribute to the regulation of the peroxisomal CoA pool and peroxisomal lipid metabolism.
Title: Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver.
Data suggest that NUDT7alpha function is tightly linked to peroxisomal CoASH/acyl-CoA homeostasis.
Title: The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit139 (e-PCR), detects polymorphism
- UniSTS:131342

AI256291 (e-PCR)
- UniSTS:159822

AU022202 (e-PCR)
- UniSTS:208334

NoName (e-PCR)
- UniSTS:236010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables coenzyme A diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables coenzyme A diphosphatase activity	TAS Traceable Author Statement more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in butyryl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within coenzyme A catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in coenzyme A catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in medium-chain fatty-acyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in propionyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in propionyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisomal matrix	TAS Traceable Author Statement more info
is_active_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxisomal coenzyme A diphosphatase NUDT7

Names: coenzyme A diphosphatase; nucleoside diphosphate-linked moiety X motif 7; nudix (nucleoside diphosphate linked moiety X)-type motif 7; nudix motif 7

NP_001277110.1

EC 3.6.1.77

NP_001277111.1

EC 3.6.1.77

NP_001363956.1

EC 3.6.1.77

NP_077757.2

EC 3.6.1.77

NP_077766.3

EC 3.6.1.77

XP_011246793.1

EC 3.6.1.77

XP_017168434.1

EC 3.6.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290181.1 → NP_001277110.1 peroxisomal coenzyme A diphosphatase NUDT7 isoform 4

See identical proteins and their annotated locations for NP_001277110.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AC121999, AF338424, AK004924

Consensus CDS

CCDS80935.1

UniProtKB/Swiss-Prot

Q99P30

Related

ENSMUSP00000104737.2, ENSMUST00000109109.8

Conserved Domains (1) summary

cd03426
Location:65 → 225

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
NM_001290182.1 → NP_001277111.1 peroxisomal coenzyme A diphosphatase NUDT7 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks a 3' exon but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC121999, AK008824, BC033046

Consensus CDS

CCDS80934.1

UniProtKB/Swiss-Prot

Q99P30

Related

ENSMUSP00000116868.2, ENSMUST00000134593.2

Conserved Domains (1) summary

cd03426
Location:41 → 121

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
NM_001377027.1 → NP_001363956.1 peroxisomal coenzyme A diphosphatase NUDT7 isoform 6

Status: VALIDATED

Source sequence(s)

AC121999

Conserved Domains (1) summary

cd03426
Location:41 → 114

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
NM_024437.4 → NP_077757.2 peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

See identical proteins and their annotated locations for NP_077757.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC121999, AF338424, AK004924

Consensus CDS

CCDS22687.1

UniProtKB/Swiss-Prot

Q6IS65, Q8BU08, Q8K260, Q99P30, Q9D0Q3, Q9DBI9

Related

ENSMUSP00000073213.6, ENSMUST00000073521.12

Conserved Domains (1) summary

cd03426
Location:41 → 201

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
NM_024446.5 → NP_077766.3 peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

See identical proteins and their annotated locations for NP_077766.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC121999, AF338424, AK004924, AK011172

Consensus CDS

CCDS22688.2

UniProtKB/Swiss-Prot

Q99P30

Related

ENSMUSP00000114598.2, ENSMUST00000147605.8

Conserved Domains (1) summary

cd03426
Location:41 → 181

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RNA

NR_165049.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121999

Related

ENSMUST00000066514.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

114860314..114881471

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248491.3 → XP_011246793.1 peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

Conserved Domains (1) summary

cd03426
Location:65 → 138

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
XM_017312945.1 → XP_017168434.1 peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

Conserved Domains (1) summary

cd03426
Location:65 → 205

CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001290180.1: Suppressed sequence

Description

NM_001290180.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.