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    Srek1 splicing regulatory glutamine/lysine-rich protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 218543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srek1provided by MGI
    Official Full Name
    splicing regulatory glutamine/lysine-rich protein 1provided by MGI
    Primary source
    MGI:MGI:2145245
    See related
    Ensembl:ENSMUSG00000032621 AllianceGenome:MGI:2145245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRrp86; Sfrs12; Srsf12; SRrp508; 8430401B01
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.3), limb E14.5 (RPKM 7.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srek1 in Genome Data Viewer
    Location:
    13 D1; 13 56.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (103873291..103911379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (103738565..103774616, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30551 Neighboring gene predicted gene, 24870 Neighboring gene peptidylprolyl isomerase A pseudogene 13_1282.1 Neighboring gene STARR-seq mESC enhancer starr_35521 Neighboring gene STARR-seq mESC enhancer starr_35522 Neighboring gene STARR-positive B cell enhancer ABC_E9155 Neighboring gene STARR-positive B cell enhancer ABC_E11783 Neighboring gene predicted gene, 52054 Neighboring gene STARR-seq mESC enhancer starr_35523 Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene STARR-positive B cell enhancer ABC_E8543 Neighboring gene STARR-seq mESC enhancer starr_35524 Neighboring gene STARR-seq mESC enhancer starr_35525 Neighboring gene STARR-seq mESC enhancer starr_35526 Neighboring gene STARR-seq mESC enhancer starr_35527 Neighboring gene STARR-seq mESC enhancer starr_35528 Neighboring gene predicted gene, 30967 Neighboring gene neurolysin (metallopeptidase M3 family)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    splicing regulatory glutamine/lysine-rich protein 1
    Names
    serine/arginine-rich splicing factor 12
    serine/arginine-rich-splicing regulatory protein 86

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361085.2 → NP_001348014.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301
      Consensus CDS
      CCDS88513.1
      Related
      ENSMUSP00000074196.7, ENSMUST00000074616.7
      Conserved Domains (2) summary
      cd12260
      Location:181 → 266
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12519
      Location:20 → 99
      RRM1_SREK1; RNA recognition motif 1 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    2. NM_001426493.1 → NP_001413422.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301

    3. NM_001426494.1 → NP_001413423.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301
      UniProtKB/Swiss-Prot
      Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4, Q8BZX4

    4. NM_001426495.1 → NP_001413424.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301
      UniProtKB/Swiss-Prot
      Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4, Q8BZX4

    5. NM_001426496.1 → NP_001413425.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301

    6. NM_172592.4 → NP_766180.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766180.1

      Status: VALIDATED

      Source sequence(s)
      AC159301
      Consensus CDS
      CCDS26743.1
      UniProtKB/Swiss-Prot
      Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4, Q8BZX4
      Related
      ENSMUSP00000147737.2, ENSMUST00000210489.2
      Conserved Domains (1) summary
      cd12260
      Location:65 → 150
      RRM2_SREK1; RNA recognition motif 2 in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    RNA

    1. NR_189738.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154310, AC159301

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      103873291..103911379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158024.1 → XP_036013917.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    2. XM_017315498.3 → XP_017170987.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    3. XM_006517608.5 → XP_006517671.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X5

    4. XM_036158020.1 → XP_036013913.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X1

      Conserved Domains (2) summary
      cd12260
      Location:181 → 266
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
      cd12519
      Location:20 → 99
      RRM1_SREK1; RNA recognition motif 1 (RRM1) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    5. XM_036158021.1 → XP_036013914.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      cd12260
      Location:65 → 150
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    6. XM_036158022.1 → XP_036013915.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4

    7. XM_006517607.4 → XP_006517670.2  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

      Conserved Domains (1) summary
      cd12260
      Location:65 → 150
      RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

    8. XM_036158023.1 → XP_036013916.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZX4.1 GenPept UniProtKB/Swiss-Prot:Q8BZX4

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