Insm1 insulinoma-associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insm1provided by MGI
Official Full Name: insulinoma-associated 1provided by MGI
Primary source: MGI:MGI:1859980
See related: Ensembl:ENSMUSG00000068154 AllianceGenome:MGI:1859980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IA-1
Summary: Predicted to enable several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and cyclin binding activity. Involved in several processes, including glandular epithelial cell differentiation; nervous system development; and norepinephrine biosynthetic process. Acts upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and type B pancreatic cell development. Located in nucleus. Is expressed in several structures, including adrenal gland; branchial arch; gut; nervous system; and sensory organ. Orthologous to human INSM1 (INSM transcriptional repressor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.33 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (146064021..146066940)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (146221997..146225020)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insm1 regulates mTEC development and immune tolerance.
Title: Insm1 regulates mTEC development and immune tolerance.
Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.
Title: Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.
Insm1 promotes differentiation of retinal progenitor cells toward photoreceptor cells in the developing retina through up-regulation of SHH.
Title: Insm1 promotes differentiation of retinal progenitor cells toward photoreceptor cells in the developing retina through up-regulation of SHH.
Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
Title: Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.
The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses beta- to delta-Cell Transdifferentiation.
Title: The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation.
HuD and miR-203a cooperatively regulate INSM1 expression.
Title: RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA.
Forced Insm1 expression in embryonic mouse neocortex causes neural progenitor cell delamination.
Title: Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.
Insm1, which encodes a zinc finger protein that is transiently expressed in nascent outer hair cells (OHC), consolidates their fate by preventing trans-differentiation into inner hair cells (IHC); in the absence of INSM1, many hair cells that are born as OHCs switch fates to become mature IHCs
Title: Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.
We conclude that decreases in Insm1 interfere with beta-cell specification during the early postnatal period and impair glucose homeostasis during metabolic stress in adults. Insm1 levels are therefore a factor that can influence the development of diabetes.
Title: Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass.
An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development.
Title: REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Insm1 (e-PCR), detects polymorphism
- UniSTS:254227

Insm1 (e-PCR), detects polymorphism
- UniSTS:531339

Insm1 (e-PCR), detects polymorphism
- UniSTS:496802

Insm1 (e-PCR), detects polymorphism
- UniSTS:547249

PMC100352P1 (e-PCR)
- UniSTS:270058

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adrenal chromaffin cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in noradrenergic neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pancreatic A cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pancreatic A cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transdifferentiation	ISO Inferred from Sequence Orthology more info
involved_in transdifferentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: insulinoma-associated protein 1

Names: insulinoma-associated protein (IA-1); zinc finger protein IA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016889.4 → NP_058585.2 insulinoma-associated protein 1

See identical proteins and their annotated locations for NP_058585.2

Status: VALIDATED

Source sequence(s)

AL935056

Consensus CDS

CCDS16830.1

UniProtKB/Swiss-Prot

Q63ZV0, Q9Z113

UniProtKB/TrEMBL

Q05BD7

Related

ENSMUSP00000092048.4, ENSMUST00000089257.6

Conserved Domains (2) summary

sd00017
Location:274 → 294

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:373 → 395

zf-C2H2; Zinc finger, C2H2 type