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    Grx3 Glutaredoxin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grx3provided by FlyBase
    Official Full Name
    Glutaredoxin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032509
    Locus tag
    Dmel_CG6523
    See related
    AllianceGenome:FB:FBgn0032509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6523; Dmel\CG6523; Grx4
    Summary
    Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in cytosol and nucleus. Is expressed in adult head and organism. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Grx3 in Genome Data Viewer
    Location:
    34B7-34B7; 2-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13366447..13367410)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13366447..13367410)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nnp-1 Neighboring gene Two A-associated protein of 42kDa Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B22 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by in silico amino acid sequence, phylogenetic and comparative structural analyses in organisms of three domains of life. Mondal S, et al. Heliyon, 2022 Oct. PMID 36203893, Free PMC Article
    2. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437
    3. The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Cygnar KD, et al. Genetics, 2005 Jun. PMID 15802506, Free PMC Article
    4. Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. Hossain MS, et al. J Cell Biol, 2023 Sep 4. PMID 37389657, Free PMC Article
    5. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Mandilaras K, et al. Metallomics, 2012 Aug. PMID 22885802

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-glutathione oxidoreductase (glutathione) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutaredoxin 3
    Names
    CG6523-PA
    Grx3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13366447..13367410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135797.3 → NP_609641.1  glutaredoxin 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJZ6
      Related
      FBpp0080044
      Conserved Domains (2) summary
      cd02984
      Location:8 → 102
      TRX_PICOT; TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an ...
      cd03028
      Location:122 → 211
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJZ6 Q9VJZ6

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