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    Bre1 Bre1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bre1provided by FlyBase
    Official Full Name
    Bre1provided by FlyBase
    Primary source
    FLYBASE:FBgn0086694
    Locus tag
    Dmel_CG10542
    See related
    AllianceGenome:FB:FBgn0086694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bre-1; Bre-1; bre1; BRE1; CG10542; dBre1; dBRE1; Dmel\CG10542; EC3-8; l(3)01640
    Summary
    Enables ubiquitin protein ligase activity. Involved in chromatin organization; positive regulation of macromolecule biosynthetic process; and protein monoubiquitination. Located in nucleus. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bre1 in Genome Data Viewer
    Location:
    64E8-64E8; 3-15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5789831..5794192, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5782931..5787292, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi Neighboring gene Cellular retinaldehyde binding protein Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary. Xuan T, et al. Dev Biol, 2013 Jul 15. PMID 23624310
    2. A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response. Cai Q, et al. Cell Rep, 2022 Dec 13. PMID 36516751
    3. Computational identification of operon-like transcriptional loci in eukaryotes. Nannapaneni K, et al. Comput Biol Med, 2013 Jul. PMID 23668349
    4. Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay. Taylor MJ, et al. J Neurogenet, 2019 Sep. PMID 31290369
    5. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Ben-Shahar Y, et al. Proc Natl Acad Sci U S A, 2007 Jan 2. PMID 17190802, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary.
      Title: dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary.
    2. identify Bre1 as a nuclear component required cell autonomously for the expression of Notch target genes in development
      Title: Bre1 is required for Notch signaling and histone modification.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bre1
    Names
    Bre1-PA
    Bre1-PB
    CG10542-PA
    CG10542-PB
    lethal (3) 01640

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5789831..5794192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300021.1 → NP_001286950.1  Bre1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
      UniProtKB/TrEMBL
      X2JGB3
      Conserved Domains (3) summary
      TIGR02168
      Location:235 → 987
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13476
      Location:654 → 762
      AAA_23; AAA domain
      pfam13923
      Location:991 → 1029
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_139732.3 → NP_647989.2  Bre1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647989.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
      UniProtKB/TrEMBL
      X2JGB3
      Related
      FBpp0076822
      Conserved Domains (3) summary
      TIGR02168
      Location:235 → 987
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13476
      Location:654 → 762
      AAA_23; AAA domain
      pfam13923
      Location:991 → 1029
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRP9.2 Q9VRP9
    X2JGB3 X2JGB3

    Gene LinkOut

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