Osbp Oxysterol binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Osbpprovided by FlyBase
Official Full Name: Oxysterol binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0020626
Locus tag: Dmel_CG6708
See related: AllianceGenome:FB:FBgn0020626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6708; Dmel\CG6708; osbp; OSBP; OSBP-Dm
Summary: Enables cholesterol transfer activity. Involved in sperm individualization and trans-Golgi network membrane organization. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval crystal cell; embryonic/larval midgut primordium; embryonic/larval salivary gland; and gut section. Orthologous to human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24934869..24938222, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20760591..20763944, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cholesterol transfer activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables sterol transfer activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-Golgi network membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain