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    Sting sting [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36016, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stingprovided by FlyBase
    Official Full Name
    stingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033453
    Locus tag
    Dmel_CG1667
    See related
    AllianceGenome:FB:FBgn0033453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1667; Dmel\CG1667; dmSTING; dSting; dSTING; STING
    Summary
    Enables 2',3'-cyclic GMP-AMP binding activity; 3',2'-cyclic GMP-AMP binding activity; and cyclic-di-GMP binding activity. Involved in several processes, including positive regulation of defense response; response to bacterium; and response to virus. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Sting in Genome Data Viewer
    Location:
    46B4-46B4; 2-61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9842686..9845512)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5730191..5733017)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lsm11 Neighboring gene Mitochondrial amidoxime reducing component Neighboring gene Vesicle-associated membrane protein 7 Neighboring gene Origin recognition complex subunit 6 Neighboring gene Proteasome alpha7 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2',3'-cyclic GMP-AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 2',3'-cyclic GMP-AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',2'-cyclic GMP-AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',2'-cyclic GMP-AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclic-di-GMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclic-di-GMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cyclic-di-GMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGAS/STING signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cGAS/STING signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of antimicrobial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sting
    Names
    CG1667-PB
    CG1667-PC
    STING
    Sting-PB
    Sting-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9842686..9845512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136681.5NP_610525.4  sting, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610525.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFY9, Q6AWJ4
      Conserved Domains (1) summary
      pfam15009
      Location:33335
      TMEM173; Transmembrane protein 173
    2. NM_001299327.1NP_001286256.1  sting, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LFY9, Q6AWJ4
      Conserved Domains (1) summary
      pfam15009
      Location:33335
      TMEM173; Transmembrane protein 173