capt capulet [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: captprovided by FlyBase
Official Full Name: capuletprovided by FlyBase
Primary source: FLYBASE:FBgn0261458
Locus tag: Dmel_CG33979
See related: AllianceGenome:FB:FBgn0261458
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Acap; acu; BcDNA:LD24380; cap; Cap; CAP; capping protein; Capt; Capulet; CG33979; CG5061; CG5074; CP; cyclase-associated protein; Dcap; Dmel\CG33979; l(2)06955; punc
Summary: Predicted to enable actin binding activity and adenylate cyclase binding activity. Involved in several processes, including cytoskeleton organization; muscle cell cellular homeostasis; and neuron development. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; amnioproctodeal invagination; epithelial furrow; and ganglia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21F1-21F1; 2-2 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1151678..1158262, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1151678..1158262, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that Capt(Capulet) and Ssh(Slingshot), but not Tsr, share overlapping functions during eye morphogenesis
Title: Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis.
Molecularly defined loss of function demonstration of actin-cofilin rods in vivo suggests that perturbations in dendrites can synergize producing severe abnormalities in mitochondria in dendrites.
Title: The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis.
DCAP is predominantly expressed in the midgut and fat bodies of late-stage embryos, suggesting a role in insulin-mediated glucose transport in these organs
Title: Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0065 (e-PCR)
- UniSTS:34516

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: capulet

Names: Act up; CG33979-PA; CG33979-PB; CG33979-PC; Cyclase-associated protein; adenylyl cyclase-associated protein; capt-PA; capt-PB; capt-PC; cyclase associated protein capulet; punctate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1151678..1158262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038780.2 → NP_001033869.1 capulet, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033869.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN55, Q9VPX7, Q9XZ60

Conserved Domains (3) summary

smart00673
Location:343 → 380

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:1 → 245

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:274 → 422

CAP_C; Adenylate cyclase associated (CAP) C terminal
NM_001272927.1 → NP_001259856.1 capulet, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259856.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN55, Q9VPX7, Q9XZ60

Conserved Domains (3) summary

smart00673
Location:343 → 380

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:1 → 245

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:274 → 422

CAP_C; Adenylate cyclase associated (CAP) C terminal
NM_001038781.2 → NP_001033870.1 capulet, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001033870.1

Status: REVIEWED

UniProtKB/TrEMBL

Q5BII8, Q9VPX6

Conserved Domains (3) summary

smart00673
Location:702 → 739

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:299 → 604

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:633 → 781

CAP_C; Adenylate cyclase associated (CAP) C terminal