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    crn crooked neck [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crnprovided by FlyBase
    Official Full Name
    crooked neckprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000377
    Locus tag
    Dmel_CG3193
    See related
    AllianceGenome:FB:FBgn0000377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    62D9.a; CG18842; CG3193; Crn; Dmel\CG3193; EG:30B8.1; l(1)2; l(1)2Fa; l(1)crn; l(1)CRN; l(1)N7; l30; N10; N5; RC63; yok
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including nervous system development; oenocyte development; and regulation of alternative mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in glioblast; larval glial cell; leg disc; and organism. Human ortholog(s) of this gene implicated in basal cell carcinoma. Orthologous to human CRNKL1 (crooked neck pre-mRNA splicing factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crn in Genome Data Viewer
    Location:
    2F2-2F2; 1-0.9 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2247594..2249983, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2141627..2144016, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) K10 Neighboring gene Odorant receptor 2a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Goebl M, et al. Trends Biochem Sci, 1991 May. PMID 1882418
    2. The crooked neck gene of Drosophila contains a motif found in a family of yeast cell cycle genes. Zhang K, et al. Genes Dev, 1991 Jun. PMID 2044955
    3. The HAT helix, a repetitive motif implicated in RNA processing. Preker PJ, et al. Trends Biochem Sci, 1998 Jan. PMID 9478129
    4. Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. Haenlin M, et al. EMBO J, 1987 Mar. PMID 16453754, Free PMC Article
    5. Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors. Raisin-Tani S, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163015

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oenocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    crooked neck
    Names
    CG3193-PA
    crn-PA
    yolky

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2247594..2249983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057770.5 → NP_477118.1  crooked neck [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46071, P17886, Q24283
      Related
      FBpp0070402
      Conserved Domains (4) summary
      pfam02184
      Location:191 → 222
      HAT; HAT (Half-A-TPR) repeat
      smart00386
      Location:94 → 122
      HAT; HAT (Half-A-TPR) repeats
      COG5107
      Location:180 → 539
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
      sd00006
      Location:109 → 139
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17886.2 P17886

    Gene LinkOut

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