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    CG3632 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3632provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030735
    Locus tag
    Dmel_CG3632
    See related
    AllianceGenome:FB:FBgn0030735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3632; MTMR3/4
    Summary
    Predicted to enable phosphatase activity and protein phosphatase binding activity. Involved in negative regulation of BMP signaling pathway. Predicted to be active in cytoplasm and membrane. Is expressed in organism. Orthologous to several human genes including MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3632 in Genome Data Viewer
    Location:
    14B9-14B9; 1-53 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16296671..16303308)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16190704..16197341)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene cabeza Neighboring gene Endoplasmic reticulum protein 44 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45485 Neighboring gene beta Hydroxy acid dehydrogenase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. Oppelt A, et al. EMBO Rep, 2013 Jan. PMID 23154468, Free PMC Article
    2. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
    3. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. Yu J, et al. J Biol Chem, 2013 Jan 4. PMID 23150675, Free PMC Article
    4. PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase. Ghosh A, et al. Life Sci Alliance, 2023 Sep. PMID 37316298, Free PMC Article
    5. The Exon Junction Complex and intron removal prevent re-splicing of mRNA. Joseph B, et al. PLoS Genet, 2021 May. PMID 34033644, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTMR4 is a necessary negative modulator for the homeostasis of BMP/Dpp signaling
      Title: Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3632-PE
    CG3632-PF
    CG3632-PG
    CG3632-PH
    CG3632-PI
    CG3632-PJ
    MYOTUBULARIN-like
    NP_001096996.1
    NP_001096997.1
    NP_001096998.1
    NP_001096999.1
    NP_727950.3
    NP_727952.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16296671..16303308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167497.3 → NP_727950.3  uncharacterized protein Dmel_CG3632, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727950.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV04
      Conserved Domains (3) summary
      cd15733
      Location:1153 → 1212
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:212 → 581
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:26 → 138
      PH-like; Pleckstrin homology-like domain

    2. NM_167499.3 → NP_727952.3  uncharacterized protein Dmel_CG3632, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727952.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPV6
      Conserved Domains (2) summary
      pfam06602
      Location:212 → 581
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:26 → 138
      PH-like; Pleckstrin homology-like domain

    3. NM_001103529.3 → NP_001096999.1  uncharacterized protein Dmel_CG3632, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV04
      Conserved Domains (3) summary
      cd15733
      Location:1153 → 1212
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:212 → 581
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:26 → 138
      PH-like; Pleckstrin homology-like domain

    4. NM_001103528.3 → NP_001096998.1  uncharacterized protein Dmel_CG3632, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096998.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV04
      Conserved Domains (3) summary
      cd15733
      Location:1153 → 1212
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:212 → 581
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:26 → 138
      PH-like; Pleckstrin homology-like domain

    5. NM_001103526.3 → NP_001096996.1  uncharacterized protein Dmel_CG3632, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU03
      Conserved Domains (3) summary
      cd15733
      Location:1162 → 1221
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:221 → 590
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:35 → 147
      PH-like; Pleckstrin homology-like domain

    6. NM_001103527.2 → NP_001096997.1  uncharacterized protein Dmel_CG3632, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JV04
      Conserved Domains (3) summary
      cd15733
      Location:1153 → 1212
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:212 → 581
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:26 → 138
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPV6 A0A023GPV6
    A8JV04 A8JV04
    Q7YU03 Q7YU03

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