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    slim scruin like at the midline [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slimprovided by FlyBase
    Official Full Name
    scruin like at the midlineprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261477
    Locus tag
    Dmel_CG5186
    See related
    AllianceGenome:FB:FBgn0261477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5186; Dmel\CG5186; l(2)s1866; Slim
    Summary
    Involved in positive regulation of stress-activated MAPK cascade. Part of Cul2-RING ubiquitin ligase complex. Is expressed in several structures, including amnioserosa; embryonic/larval midgut primordium; ganglia; mesoderm; and visceral mesoderm derivative. Orthologous to human KLHDC10 (kelch domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slim in Genome Data Viewer
    Location:
    55C9-55C9; 2-85 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18440965..18445526)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14328470..14333031)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene TRPL translocation defect 14 Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19 Neighboring gene roswell

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Sekine Y, et al. Mol Cell, 2012 Dec 14. PMID 23102700
    2. The quantitative genetic basis of male mating behavior in Drosophila melanogaster. Moehring AJ, et al. Genetics, 2004 Jul. PMID 15280239, Free PMC Article
    3. The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects. Lobell AS, et al. G3 (Bethesda), 2017 Jul 5. PMID 28550012, Free PMC Article
    4. MidExDB: a database of Drosophila CNS midline cell gene expression. Wheeler SR, et al. BMC Dev Biol, 2009 Nov 10. PMID 19903351, Free PMC Article
    5. Gene regulatory networks during the development of the Drosophila visual system. Chen YC, et al. Curr Top Dev Biol, 2020. PMID 32450970, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scruin like at the midline
    Names
    CG5186-PA
    CG5186-PC
    lethal (2) s1866
    slim-PA
    slim-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18440965..18445526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079058.3 → NP_523782.1  scruin like at the midline, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZB86, Q7JR76
      Related
      FBpp0085872
      Conserved Domains (3) summary
      sd00038
      Location:203 → 263
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:325 → 372
      Kelch_1; Kelch motif
      pfam13418
      Location:441 → 492
      Kelch_4; Galactose oxidase, central domain

    2. NM_166289.2 → NP_725794.2  scruin like at the midline, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725794.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZB86, Q7JR76
      Conserved Domains (3) summary
      sd00038
      Location:203 → 263
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:325 → 372
      Kelch_1; Kelch motif
      pfam13418
      Location:441 → 492
      Kelch_4; Galactose oxidase, central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB86.2 A1ZB86
    Q95TX5 Q95TX5

    Gene LinkOut

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