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    Hml Hemolectin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39529, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Hmlprovided by FlyBase
    Official Full Name
    Hemolectinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029167
    Locus tag
    Dmel_CG7002
    See related
    AllianceGenome:FB:FBgn0029167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7002; CT21553; d-hml; Dmel\CG7002; hml
    Summary
    Enables protein homodimerization activity. Involved in hemolymph coagulation. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; cortical zone of lymph gland primary lobe; embryonic/larval hemolymph; and hemocyte. Human ortholog(s) of this gene implicated in asthma; dry eye syndrome; lung disease (multiple); and urinary bladder cancer. Orthologous to several human genes including SSPOP (SCO-spondin, pseudogene); MUC2 (mucin 2, oligomeric mucus/gel-forming); and MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hml in Genome Data Viewer
    Location:
    70C4-70C5; 3-41 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13846054..13860001)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13839154..13853101)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 68C Neighboring gene uncharacterized protein Neighboring gene dyschronic Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hemocyte-targeted gene expression in the female malaria mosquito using the hemolectin promoter from Drosophila. Pondeville E, et al. Insect Biochem Mol Biol, 2020 May. PMID 32105779, Free PMC Article
    2. Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii. Garcia-Arraez MG, et al. BMC Microbiol, 2019 Feb 20. PMID 30786854, Free PMC Article
    3. Detecting proliferation of adult hemocytes in Drosophila by BrdU incorporation. Ghosh S, et al. Wellcome Open Res, 2018. PMID 29946570, Free PMC Article
    4. A Drosophila haemocyte-specific protein, hemolectin, similar to human von Willebrand factor. Goto A, et al. Biochem J, 2001 Oct 1. PMID 11563973, Free PMC Article
    5. Hemocytes are essential for Drosophila melanogaster post-embryonic development, independent of control of the microbiota. Stephenson HN, et al. Development, 2022 Sep 15. PMID 36093870, Free PMC Article

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study describes the isolation of a new hml allele in a forward screen for coagulation mutants, and characterization of this and two other hml alleles; findings demonstrate an immunological role of hemolectin
      Title: A role for Hemolectin in coagulation and immunity in Drosophila melanogaster.
    2. Data from an experiment demonstrating the inducible expression of Hml double-stranded RNA (dsRNA) indicate that a slow rate of engulfment of larval cells results in a longer time to emergence.
      Title: Exposure to low-dose X-rays promotes peculiar autophagic cell death in Drosophila melanogaster, an effect that can be regulated by the inducible expression of Hml dsRNA.
    3. Hemolectin(Hml) is involved in hemostasis and/or coagulation in Drosophila larvae.
      Title: Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hemolymph coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hemolectin
    Names
    CG7002-PA
    CG7002-PB
    Hml-PA
    Hml-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13846054..13860001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079336.3 → NP_524060.2  hemolectin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524060.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U5D0, Q9VU94
      Related
      FBpp0075495
      Conserved Domains (10) summary
      smart00216
      Location:840 → 1015
      VWD; von Willebrand factor (vWF) type D domain
      smart00231
      Location:2299 → 2404
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00832
      Location:1054 → 1121
      C8; This domain contains 8 conserved cysteine residues
      cd00057
      Location:2089 → 2223
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam01826
      Location:1131 → 1185
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3257 → 3313
      C8; C8 domain
      pfam13330
      Location:1751 → 1837
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      cl02516
      Location:3035 → 3198
      VWD; von Willebrand factor type D domain
      cl17735
      Location:3397 → 3451
      VWC; von Willebrand factor type C domain
      cl21545
      Location:3755 → 3813
      GHB_like; Glycoprotein hormone beta chain homologues

    2. NM_001274880.1 → NP_001261809.1  hemolectin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCE5, Q9U5D0
      Conserved Domains (10) summary
      smart00216
      Location:839 → 1014
      VWD; von Willebrand factor (vWF) type D domain
      smart00231
      Location:2298 → 2403
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00832
      Location:1053 → 1120
      C8; This domain contains 8 conserved cysteine residues
      cd00057
      Location:2088 → 2222
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam01826
      Location:1130 → 1184
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:3256 → 3312
      C8; C8 domain
      pfam13330
      Location:1750 → 1836
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      cl02516
      Location:3034 → 3197
      VWD; von Willebrand factor type D domain
      cl17735
      Location:3396 → 3450
      VWC; von Willebrand factor type C domain
      cl21545
      Location:3754 → 3812
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCE5 M9PCE5
    Q8MS79 Q8MS79
    Q9U5D0 Q9U5D0
    Q9VU94 Q9VU94

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