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    phtf phtf [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35583, updated on 17-Dec-2024

    Summary

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    Official Symbol
    phtfprovided by FlyBase
    Official Full Name
    phtfprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028579
    Locus tag
    Dmel_CG3268
    See related
    AllianceGenome:FB:FBgn0028579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.GH08636; BcDNA:GH08636; CG3268; d-phtf; Dmel\CG3268
    Summary
    Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic ventral epidermis; embryonic/larval dorsal vessel; and male germline stem cell. Orthologous to human PHTF1 (putative homeodomain transcription factor 1) and PHTF2 (putative homeodomain transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See phtf in Genome Data Viewer
    Location:
    42C7-42C7; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6741899..6746141)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2629404..2633646)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Zinc/iron regulated transporter-related protein 42C.2 Neighboring gene hulk Neighboring gene Methylcrotonoyl-CoA carboxylase 2 Neighboring gene Eb1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals. Manuel A, et al. Genomics, 2000 Mar 1. PMID 10729229
    2. Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins. Benton R, et al. Elife, 2023 Feb 20. PMID 36803935, Free PMC Article
    3. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article
    4. The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Devineni AV, et al. Fly (Austin), 2011 Jul-Sep. PMID 21750412, Free PMC Article
    5. Enhancer modeling uncovers transcriptional signatures of individual cardiac cell states in Drosophila. Busser BW, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25609699, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phtf
    Names
    CG3268-PA
    phtf-PA
    putative homeodomain transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6741899..6746141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136388.3 → NP_610232.1  phtf [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TW25, Q9V9A8
      Related
      FBpp0085459
      Conserved Domains (1) summary
      pfam12129
      Location:3 → 184
      Phtf-FEM1B_bdg; Male germ-cell putative homeodomain transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9A8.2 Q9V9A8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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