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    Atg18b Autophagy-related 18b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atg18bprovided by FlyBase
    Official Full Name
    Autophagy-related 18bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032935
    Locus tag
    Dmel_CG8678
    See related
    AllianceGenome:FB:FBgn0032935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Atg18; ATG18; Atg18-like; ATG18.2; atg18b; CG8678; Dmel\CG8678; l(2)k09410
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in cellular response to oxidative stress. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atg18b in Genome Data Viewer
    Location:
    39B3-39B3; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21212322..21220572, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21212322..21220572, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene clumsy Neighboring gene small nuclear RNA U4 at 39B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45713 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagic cell death: Loch Ness monster or endangered species? Shen HM, et al. Autophagy, 2011 May. PMID 21150268
    2. The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. Vanhauwaert R, et al. EMBO J, 2017 May 15. PMID 28331029, Free PMC Article
    3. Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila. Nagata R, et al. Curr Biol, 2022 Mar 14. PMID 35134324
    4. Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila. Nagy P, et al. FEBS Lett, 2014 Jan 31. PMID 24374083, Free PMC Article
    5. Drosophila to Explore Nucleolar Stress. DeLeo KR, et al. Int J Mol Sci, 2021 Jun 23. PMID 34201772, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related 18b
    Names
    Atg18b-PA
    Atg18b-PB
    Autophagy-specific gene 18b
    CG8678-PA
    CG8678-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21212322..21220572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273738.1 → NP_001260667.1  Autophagy-related 18b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZU9, Q9VIE1
      Conserved Domains (3) summary
      COG2319
      Location:9 → 281
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:79 → 122
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:89 → 242
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_136256.4 → NP_610100.1  Autophagy-related 18b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610100.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZU9, Q9VIE1
      Related
      FBpp0081016
      Conserved Domains (3) summary
      COG2319
      Location:9 → 281
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:79 → 122
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:89 → 242
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIE1 Q9VIE1

    Gene LinkOut

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