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    HP5 Heterochromatin protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32090, updated on 17-Dec-2024

    Summary

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    Official Symbol
    HP5provided by FlyBase
    Official Full Name
    Heterochromatin protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030301
    Locus tag
    Dmel_CG1745
    See related
    AllianceGenome:FB:FBgn0030301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1745; Dmel\CG1745
    Summary
    Located in chromocenter and heterochromatin. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HP5 in Genome Data Viewer
    Location:
    10B14-10B14; 1-34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11454786..11459227)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11348819..11353260)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glutamine synthetase 2 Neighboring gene Ecotropic viral integration site 5 Neighboring gene Sphingosine kinase 1 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4g15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phase separation drives heterochromatin domain formation. Strom AR, et al. Nature, 2017 Jul 13. PMID 28636597, Free PMC Article
    2. HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila. Greil F, et al. EMBO J, 2007 Feb 7. PMID 17255947, Free PMC Article
    3. Functional conservation of the Drosophila hybrid incompatibility gene Lhr. Brideau NJ, et al. BMC Evol Biol, 2011 Mar 2. PMID 21366928, Free PMC Article
    4. Stepwise evolution of essential centromere function in a Drosophila neogene. Ross BD, et al. Science, 2013 Jun 7. PMID 23744945, Free PMC Article
    5. Global chromatin domain organization of the Drosophila genome. de Wit E, et al. PLoS Genet, 2008 Mar 28. PMID 18369463, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterochromatin protein 5
    Names
    CG1745-PA
    CG1745-PB
    CG1745-PC
    HP5-PA
    HP5-PB
    HP5-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11454786..11459227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132490.3 → NP_572718.2  heterochromatin protein 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572718.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYY7
      Related
      FBpp0073348
      Conserved Domains (1) summary
      PTZ00341
      Location:458 → 745
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional

    2. NM_001272522.1 → NP_001259451.1  heterochromatin protein 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHL2
      Conserved Domains (1) summary
      PLN03237
      Location:66 → 248
      PLN03237; DNA topoisomerase 2; Provisional

    3. NM_206686.3 → NP_996409.1  heterochromatin protein 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960N6
      Conserved Domains (1) summary
      PLN03237
      Location:66 → 248
      PLN03237; DNA topoisomerase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHL2 M9PHL2
    Q960N6 Q960N6
    Q9VYY7 Q9VYY7

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