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    drn doctor no [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    drnprovided by FlyBase
    Official Full Name
    doctor noprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266410
    Locus tag
    Dmel_CG45050
    See related
    AllianceGenome:FB:FBgn0266410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-85Da; anon-EST:fe1B11; anon-EST:fe2G11; BcDNA:RE70963; CG16750; CG16751; CG30492; CG33187; CG33188; CG33936; CG33937; CG43674; CG45050; Dmel\CG45050
    Old locus tag
    Dmel_CG33937; Dmel_CG43674
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in determination of digestive tract left/right asymmetry and positive regulation of receptor signaling pathway via JAK-STAT. Is active in cytoplasm. Is expressed in organism; spermatozoon; and wing disc. Orthologous to human ZFAND5 (zinc finger AN1-type containing 5) and ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See drn in Genome Data Viewer
    Location:
    85D11-85D11; 3-48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9340216..9362994)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5165938..5188716)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43301 Neighboring gene pasiflora 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serine racemase Neighboring gene FER tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis. Lai YT, et al. Development, 2023 Mar 15. PMID 36861793, Free PMC Article
    2. Molecular and genetic organization of Drosophila melanogaster polytene chromosomes: evidence for two types of interband regions. Demakov S, et al. Genetica, 2004 Nov. PMID 15609554
    3. A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila. Bonin CP, et al. Genetics, 2004 Aug. PMID 15342518, Free PMC Article
    4. The Fes/Fer non-receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila. Murray MJ, et al. Development, 2006 Aug. PMID 16831834
    5. Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution. Lu TC, et al. Science, 2023 Jun 16. PMID 37319212, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 9361869-9362054 mobile_element_type = transposon:pogo{}1279

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of digestive tract left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    doctor no
    Names
    CG45050-PB
    CG45050-PC
    CG45050-PD
    CG45050-PE
    CG45050-PF
    CG45050-PG
    CG45050-PH
    CG45050-PI
    anon-fast-evolving-1B11
    anon-fast-evolving-2G11
    drn-PB
    drn-PC
    drn-PD
    drn-PE
    drn-PF
    drn-PG
    drn-PH
    drn-PI

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9340216..9362994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031991.3 → NP_001027162.1  doctor no, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    2. NM_001275480.2 → NP_001262409.1  doctor no, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    3. NM_001300317.1 → NP_001287246.1  doctor no, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    4. NM_001275478.2 → NP_001262407.1  doctor no, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262407.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    5. NM_001275479.2 → NP_001262408.1  doctor no, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    6. NM_001031990.4 → NP_001027161.1  doctor no, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ62, Q9VHF4
      Conserved Domains (3) summary
      smart00154
      Location:140 → 177
      ZnF_AN1; AN1-like Zinc finger
      TIGR00601
      Location:37 → 120
      rad23; UV excision repair protein Rad23
      pfam01754
      Location:11 → 32
      zf-A20; A20-like zinc finger

    7. NM_001275481.2 → NP_001262410.2  doctor no, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262410.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGY1
      Conserved Domains (1) summary
      smart00154
      Location:124 → 161
      ZnF_AN1; AN1-like Zinc finger

    8. NM_001300318.1 → NP_001287247.1  doctor no, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGY1
      Conserved Domains (1) summary
      smart00154
      Location:124 → 161
      ZnF_AN1; AN1-like Zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGY1 A0A0B4KGY1
    Q8T3W4 Q8T3W4
    Q9VHF4 Q9VHF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials