Cul5 Cullin 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cul5provided by FlyBase
Official Full Name: Cullin 5provided by FlyBase
Primary source: FLYBASE:FBgn0288875
Locus tag: Dmel_CG1401
See related: AllianceGenome:FB:FBgn0288875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1401; cul-5; Cul-5; cul5; CUL5; Cullin5; Dmel\CG1401; shkl
Summary: Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; oogenesis; and sensory organ precursor cell fate determination. Part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including adult head; anterior-posterior compartment boundary of the antennal disc; epithelium; ganglia; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29059272..29062975, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24884994..24888697, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila
Title: Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila.
Data show that the follicular epithelium that normally encapsulates single germ line cysts develops aberrantly in cul-5 mutant.
Title: Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis.
cul-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development.
Title: Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin ligase complex scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IC Inferred by Curator more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul5-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain