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    AstA-R2 Allatostatin A receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AstA-R2provided by FlyBase
    Official Full Name
    Allatostatin A receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039595
    Locus tag
    Dmel_CG10001
    See related
    AllianceGenome:FB:FBgn0039595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0131005.7; anon-WO0170980.115; anon-WO0170980.116; AR-2; AstA R2; AstR; ASTR; CG10001; D.AlstR2; DAR; Dar-2; DAR-2; Dar2; DAR2; Dmel\CG10001
    Summary
    Enables allatostatin receptor activity. Involved in neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including adult brain; adult fat body; adult pars intercerebralis; crop; and gut section. Orthologous to several human genes including GALR2 (galanin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AstA-R2 in Genome Data Viewer
    Location:
    98E2-98E3; 3-97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28737109..28744782, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24562831..24570504, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene snustorr Neighboring gene huntingtin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of four Drosophila allatostatins as the cognate ligands for the Drosophila orphan receptor DAR-2. Lenz C, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527415
    2. Immunocytochemical analysis of putative allatostatin receptor (DAR-2) distribution in the CNS of larval Drosophila melanogaster. Bowser PR, et al. Peptides, 2005 Jan. PMID 15626507
    3. Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster. Lenz C, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873647
    4. The FGLamide-allatostatins influence foraging behavior in Drosophila melanogaster. Wang C, et al. PLoS One, 2012. PMID 22558326, Free PMC Article
    5. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells. Larsen MJ, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527383

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables allatostatin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables allatostatin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allatostatin A receptor 2
    Names
    ASA-receptor
    AstA-R2-PA
    AstA-R2-PB
    AstA-R2-PC
    CG10001-PA
    CG10001-PB
    CG10001-PC
    allatostatin receptor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28737109..28744782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079820.3 → NP_524544.1  allatostatin A receptor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBC8, Q9VAU0
      Related
      FBpp0084685
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 313
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:47 → 164
      7tm_4; Olfactory receptor

    2. NM_001276113.1 → NP_001263042.1  allatostatin A receptor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263042.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NBC8, Q9VAU0
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 313
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:47 → 164
      7tm_4; Olfactory receptor

    3. NM_001260423.2 → NP_001247352.1  allatostatin A receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V7
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 313
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:47 → 164
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D6W4V7 D6W4V7
    Q9NBC8 Q9NBC8

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