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    CG4360 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4360provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038787
    Locus tag
    Dmel_CG4360
    See related
    AllianceGenome:FB:FBgn0038787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4360
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human ZNF355P (zinc finger protein 355, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4360 in Genome Data Viewer
    Location:
    92E2-92E3; 3-68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20324274..20328003, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16149996..16153725, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Oxysterol-binding protein-related protein 8 Neighboring gene antisense RNA:CR45800 Neighboring gene Sirtuin 2 Neighboring gene Ionotropic receptor 92a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Enuameh MS, et al. Genome Res, 2013 Jun. PMID 23471540, Free PMC Article
    2. Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature. Zane F, et al. Aging Cell, 2023 Nov. PMID 37822253, Free PMC Article
    3. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila. Han Y, et al. Elife, 2017 Aug 14. PMID 28806173, Free PMC Article
    4. Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism. Blatti C, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25791631, Free PMC Article
    5. Pervasive variation of transcription factor orthologs contributes to regulatory network evolution. Nadimpalli S, et al. PLoS Genet, 2015 Mar. PMID 25748510, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4360-PA
    CG4360-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20324274..20328003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142622.3 → NP_650879.1  uncharacterized protein Dmel_CG4360, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDN4
      Related
      FBpp0083307
      Conserved Domains (3) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:157 → 181
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:287 → 363
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001104374.3 → NP_001097844.1  uncharacterized protein Dmel_CG4360, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R02
      Conserved Domains (3) summary
      sd00017
      Location:144 → 164
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:157 → 181
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:287 → 363
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29R02 Q29R02
    Q9VDN4 Q9VDN4

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